Glutaraldehyde-induced porcine model mimics human chronic wounds: insights into pathophysiology and therapeutic applications [0.03%]
戊二醛诱导的慢性伤口猪模型及其病理生理和治疗应用研究
Shahriar Sharifi,Renee Munoz,Anthony McElwain et al.
Shahriar Sharifi et al.
Chronic wounds present a significant clinical challenge due to their complex pathophysiology and resistance to standard treatments. A key obstacle in developing therapies is the lack of animal models that accurately mimic human chronic woun...
CRISPR screen-based mammalian cell engineering for complex biotherapeutics [0.03%]
基于CRISPR筛选的哺乳动物细胞工程复杂生物药物
Sung Wook Shin,Gyun Min Lee,Jae Seong Lee
Sung Wook Shin
The rise of complex biotherapeutics has introduced bottlenecks in production using mammalian cells. Clustered regularly interspaced short palindromic repeats (CRISPR)-based screens enable unbiased discovery of engineering targets that mitig...
Leveraging stability dynamics of spore germination for microbially enhanced mineralization of bioconcrete [0.03%]
利用孢子萌发的稳定性动力学促进生物混凝土的微生物矿化作用
Ankita Debnath,Mihir Kumar Choudhury,Damodar Maity et al.
Ankita Debnath et al.
Microbially induced biomineralization (MIBM) is a trending biotechnological application with the potential to be used in the engineering of built environment; however, it is limited by premature germination of spores due to stresses during ...
Gene therapy strategies in tissue engineering: advances and applications for regenerative therapy [0.03%]
基因治疗策略在组织工程学中的应用及再生疗法中的进展和应用
Hasan Akbaba,Lucy Homer,Thi Bao Tram Tran et al.
Hasan Akbaba et al.
Gene therapy has emerged as a promising strategy for tissue regeneration, offering the potential to address the limitations of conventional treatments. In this review we present an overview of applications of gene therapy in tissue regenera...
Creating artificial miR2118a/b to boost yield and broad-spectrum resistance in soybean via CRISPR/Cas9-targeted mutation [0.03%]
利用CRISPR/Cas9靶向突变创建人工miR2118a/b以提高大豆产量和广谱抗性
Limiao Chen,Wenqi Ouyang,Yanfeng Hu et al.
Limiao Chen et al.
While regulatory functions of mature miRNAs are well established, the functions of miRNAs* and their potential for genetic engineering in crop improvement remain underexplored. Here, we used clustered regularly interspaced short palindromic...
Fang Ba,Qing Sun
Fang Ba
Chromoproteins (homologous to fluorescent proteins identified initially in marine organisms) are visible to the naked eye under white light. Their unique advantages - including robust expression in both prokaryotic and eukaryotic systems, b...
Yuyong Hou,Suihao Yan,Longjiang Yu et al.
Yuyong Hou et al.
Kleptosomes - specialized organelles in sea slugs that hijack chloroplasts - illuminate pathways for synthetic organelle engineering. Their unique mechanisms of organelle integration, energy coupling, and stress-responsive adaptation offer ...
Tobias John,Gudrun Vogtentanz
Tobias John
Intramuscular delivery of mRNA-encoded single-chain variable fragments prevents myotoxin II-induced skeletal muscle damage in a preclinical model [0.03%]
一种用于临床前模型的新型肌肉递送mRNA技术，可防止肌毒素II引起的骨骼肌损伤
José R Almeida,Christoffer V Sørensen,Soheil Gilabadi et al.
José R Almeida et al.
Antivenom is the only effective treatment for snakebites, but it often fails to tackle venom-induced local tissue/muscle damage, leading to permanent disabilities. We investigated whether monoclonal single-chain variable fragments (scFvs) t...
Elevated carbon dioxide stimulates efficient organic carbon consumption for the unicellular alga Galdieria [0.03%]
高二氧化碳促进原绿球藻高效利用有机碳元素
Mauricio Lopez Portillo Masson,Bárbara Bastos de Freitas,Andrei Zybinskii et al.
Mauricio Lopez Portillo Masson et al.
Unicellular algae are appealing for nutritional and biotechnological utility, but show wide variation across strains and can be challenging to produce. Species in the thermo-acidophilic genus Galdieria use diverse organic carbon sources for...