Industrialization of 3D hiPSC-cardiac microtissues for high-throughput cardiac safety and drug discovery screening [0.03%]
用于心脏安全和药物发现筛选的3D人诱导多能干细胞心脏微组织工业化
Tessa de Korte,Benjamin B Johnson,Georgios Kosmidis et al.
Tessa de Korte et al.
Current cardiac cell models for drug screening often face a trade-off between cellular maturity and throughput. 3D human-induced pluripotent stem cell (hiPSC)-based heart models typically exhibit adult-like features, but their use often req...
Engineering and characterization of small-molecule transporters for cell factories [0.03%]
细胞工厂中小分子转运蛋白的工程设计与表征
Yuesheng Zhang,Douglas B Kell,Irina Borodina
Yuesheng Zhang
Membrane transporters play crucial roles in metabolite exchange, cellular communication, and metabolic homeostasis and are attractive targets in metabolic engineering for the development of microbial cell factories. While transporter engine...
Reimagining colour with synthetic biology [0.03%]
合成生物学重塑色彩 councilllardddlarNDARUIDAUIDWQADQQDAWQDAAWQAQQAXXCAASCNCOUHDLRKLBNMFEWFQAWEDCFTYGHJUKIOPL;VNSAJFHAKSJHFAPSWQECASDFVZXCVBNMK assaulteddddаслал assaultassaultassaultassaultassaltassaolt assaultassaultassaultassaultassaultassaultassaultassaultassaul assaultassaultassaut assaultassaultassaulta
Nick Milne
Nick Milne
Mauro Mandrioli
Mauro Mandrioli
Personal genomics and gene editing raise the prospect of undetectable gene doping. Athletes' genome sequencing should be integrated into the Athlete Biological Passport to deter future abuse. This provocative vision calls for urgent debate ...
Advances in lung biomimetic systems: exploring biophysical cues in lung regenerative medicine [0.03%]
仿生肺系统研究进展：探索肺再生医学中的生物物理因素
Shiyuan Bian,Jason Say,Dana Brinson et al.
Shiyuan Bian et al.
The COVID-19 pandemic highlighted the urgent need for advanced lung regenerative medicine. While traditional research focused on biochemical pathways, biophysical cues are equally critical regulators of lung cell behavior. This review discu...
Harnessing piezoelectricity for musculoskeletal regeneration: microcurrents to tissue repair [0.03%]
压电效应在骨肌肉组织修复中的应用：微电流促进组织修复
Taraje Whitfield,Fatemeh S Hosseini,Thanh D Nguyen et al.
Taraje Whitfield et al.
Piezoelectric scaffolds are emerging as promising therapeutic strategies for musculoskeletal regeneration. These materials convert mechanical forces, ranging from intrinsic motion to focused ultrasound (US) force, into localized electrical ...
Techno-economic assessment-guided biofoundry for microbial strain development [0.03%]
基于 techno-economic 评估的生物工厂菌株开发方法学指导
Yu Been Heo,Sung Cheon Ko,Jay D Keasling et al.
Yu Been Heo et al.
A biofoundry integrates laboratory automation with Design-Build-Test-Learn (DBTL) workflows to accelerate strain development for sustainable manufacturing. Quantifying the economic efficiency of automated processes remains challenging. Here...
Discovery, characterization, and application of chromosomal integration sites in the hyperthermophilic archaeon Sulfolobus islandicus [0.03%]
栖热菌Sulfolobus islandicus染色体整合位点的鉴定、表征及应用
Aashutosh Girish Boob,Changyi Zhang,Yuwei Pan et al.
Aashutosh Girish Boob et al.
Sulfolobus islandicus, an emerging archaeal model organism, offers unique advantages for metabolic engineering and synthetic biology applications owing to its ability to thrive in extreme environments. Although several genetic tools have be...
Comparison of technologies for manufacturing extracellular vesicles for therapeutic applications [0.03%]
用于治疗应用的细胞外囊泡制造技术比较
Selen Uman,Kendra Worthington,Jessica Dominic et al.
Selen Uman et al.
Extracellular vesicles (EVs) have gained significant attention as therapeutics, building from natural mechanisms of paracrine signaling. The field has evolved with substantial heterogeneity in methods to isolate and characterize EVs and new...
Glutaraldehyde-induced porcine model mimics human chronic wounds: insights into pathophysiology and therapeutic applications [0.03%]
戊二醛诱导的慢性伤口猪模型及其病理生理和治疗应用研究
Shahriar Sharifi,Renee Munoz,Anthony McElwain et al.
Shahriar Sharifi et al.
Chronic wounds present a significant clinical challenge due to their complex pathophysiology and resistance to standard treatments. A key obstacle in developing therapies is the lack of animal models that accurately mimic human chronic woun...