Chao Li,Desheng Mei,Hongtao Cheng et al.
Chao Li et al.
Conventional plant genome editing relies on tissue culture-mediated somatic cell regeneration, a technically demanding process that limits its application across diverse species. Emerging strategies now circumvent this bottleneck by enablin...
Dexter Achu Mosoh,Wagner A Vendrame
Dexter Achu Mosoh
The 'predatory replacement' model in agriculture is untenable. We propose a symbiotic framework valorizing farmer-supplied agricultural waste side-streams to fuel bioengineered plant callus for decentralized high-value metabolite biosynthes...
Growth-coupled evolution accelerates efficient biosynthesis of natural products [0.03%]
生长耦合进化加速天然产物的高效生物合成
Minjun Chang,Kyubin Shim,Dongsoo Yang
Minjun Chang
Microbial natural product biosynthesis often suffers from metabolic burden and genetic instability. Bushin et al. introduce a synthetic C1 feedback loop that couples xanthommatin production to cell survival, enabling adaptive laboratory evo...
Multifunctional biosensors redefining liquid biopsy: advancing simultaneous multianalyte detection [0.03%]
多功能生物传感器重新定义液体活检：同时多重分析物检测的发展趋势
Panagiota M Kalligosfyri,Antonella Miglione,Ada Raucci et al.
Panagiota M Kalligosfyri et al.
Liquid biopsy has revolutionized noninvasive disease diagnosis and monitoring by detecting circulating biomarkers such as tumor-derived DNA, miRNAs, proteins, exosomes, and circulating tumor cells in body fluids. Conventional single-analyte...
Decode and rewire: programming Komagataella phaffii for bioproduction with synthetic transcriptional tools [0.03%]
解码与重构：利用合成转录工具对Komagataella phaffii进行生物生产编程
Xigang Wei,Wenjie Cong,Hualan Zhou et al.
Xigang Wei et al.
The yeast Komagataella phaffii is a leading producer of secreted therapeutic and industrial proteins. Its excellent traits make it a primary host for the production of value-added carbon compounds, including native metabolites, heterologous...
Engineering Halomonas for low-salt, open, and unsterile production of polyhydroxybutyrate [0.03%]
工程改造海莫单胞菌在低盐、开放且非无菌条件下生产聚羟基丁酸酯
Simian Sun,Mingwei Shao,Qitiao Hu et al.
Simian Sun et al.
Halophiles enable convenient open, unsterile cultivation, but excessive salinity causes downstream burdens. This study engineered Halomonas bluephagenesis via genome editing, adaptive evolution, and metabolic rewiring to create a series of ...
Chantel Nin Xuan Kuek,Ratima Suntornnond,Wee Swan Yap et al.
Chantel Nin Xuan Kuek et al.
Cultivated meat is a promising solution to global food security challenges, but cultivated ingredients offer an equally compelling and potentially more economically stable path forward. Components such as flavour enhancers, cultivated fat, ...
An immune-inspired intelligent aptasensor with broad detection capability [0.03%]
一种免疫启发的智能适配子传感器，具有广泛的检测能力
Nan Li,Kaiyue Wei,Yuyang Zhang et al.
Nan Li et al.
Biosensors, particularly aptasensors, play a pivotal role in rapid diagnostics, but their practical performance is limited by suboptimal aptamers and conventional aptamer-material combination-based approaches. To overcome the limitations, w...
Elucidation of odd-chain dicarboxylate metabolism in Acinetobacter baylyi and application to polyethylene upcycling [0.03%]
解链霉菌奇数碳二羧酸代谢及在聚乙烯化学升级回收中的应用
Yuxin Tian,Seong-Min Cho,Sunkyu Park et al.
Yuxin Tian et al.
Polyethylene (PE) is a versatile polymer, but its end-of-life management is challenging due to its recalcitrant structure. We present a promising approach combining chemical degradation and bio-upcycling to convert postconsumer PE waste int...
Qihang Chen,Changtai Zhang,Song Liu et al.
Qihang Chen et al.
Steroid hormones are key signaling molecules regulating growth, metabolism, reproduction, and stress adaptation and are widely used as essential pharmaceuticals. Traditional production from sterol feedstocks through multistep chemical or mi...