Peter Battle,Ying Chen
Peter Battle
Hydrogen fermentation can generate protein-rich microbial biomass without agricultural carbon feedstocks, but cultivation alone does not create a food ingredient. Woern and colleagues establish a targeted route for protein recovery from Cup...
Affinity chromatography in vaccine manufacturing: from capture technology to quality-defining bioprocessing [0.03%]
疫苗制造中的亲和色谱法：从捕获技术到定义质量的生物加工
Ayşegül Bülbül,Ateş Kara,Adil Denizli
Ayşegül Bülbül
Protein-based and particulate vaccines are vital for rapid infectious disease response, but downstream purification often limits their manufacture. These heterogeneous, fragile products resist separation from complex impurities using conven...
Yonatan Chemla,Christopher A Voigt
Yonatan Chemla
Fifty years after the original Asilomar Meeting on Recombinant DNA, new stakeholders in biotechnology reconvened at the Spirit of Asilomar and Future of Biotechnology 2025 Conference. The objective was the responsible advancement of biotech...
Engineering energy-robust Clostridium autoethanogenum via integrated nanotechnology and transcription-guided metabolic reprogramming [0.03%]
基于纳米技术和转录调控的代谢重编程打造乙醇梭菌(autoethanogenum)合成燃料乙醇体系
Yida Zhai,Limei Chen,Fuguo Liu et al.
Yida Zhai et al.
Microbial conversion of CO and CO2 offers a promising route to C1 gas valorization, but acetogenic syngas fermentation remains constrained by bioenergetic bottlenecks. To address this, a biohybrid system integrating bovine serum albumin-sta...
In vivo translation of DNA origami: a virus-like particle design framework [0.03%]
DNA折纸的体内转译：一个病毒样颗粒设计框架
Kousha Kamal,Eric S Y Chiu,Ziji Guo et al.
Kousha Kamal et al.
DNA origami nanostructures are self-assembling nanostructures being developed as vaccines, therapeutics, and drug delivery systems. Despite impressive advances, physiological barriers have limited their clinical translation. This review pro...
A rapid and high-throughput biotechnology quantifies major glycoforms of human IgG1 mAb drugs [0.03%]
一种快速高效的生物技术可量化人源IgG1单克隆抗体药物的主要糖型
Yasuyuki Matsumoto,Linjiao Zhou,Shiho Ohno et al.
Yasuyuki Matsumoto et al.
Human IgG1 monoclonal antibody (mAb) drugs are widely manufactured using mammalian cells and contain three major glycoforms on asparagine residue at position 297 (Asn297) in their Fc region: fucosylated, afucosylated, and high-mannose glyca...
Wilson Wen Bin Goh,Cheng Chang,Hui Peng et al.
Wilson Wen Bin Goh et al.
π-HuB is an international consortium that aims to reframe proteomics from a catalog of proteins into a navigator of biological transitions. By integrating proteomic data, AI, standards, governance, and international infrastructure, it coul...
Anna M Duraj-Thatte
Anna M Duraj-Thatte
Chemical stimulation represents a new strategy for controlling bioluminescence in engineered living materials (ELMs). Brachi et al. demonstrate that embedding the naturally bioluminescent dinoflagellate Pyrocystis lunula within 3D-printed h...
Shuo Yang,Cong Gao,Guipeng Hu et al.
Shuo Yang et al.
Yeast is widely used as a microbial chassis for sustainable chemical production, with subcellular organelles helping to organize and regulate biosynthesis. Among these organelles, mitochondria play pivotal roles in yeast cell factories by s...
Point-of-care GlycoStrips detect serum and salivary antibodies to blood group antigens and pathogens [0.03%]
现场检测用的GlycoStrip试纸可以检测血型抗原和病原体的血液及唾液抗体
Tianwei Jia,Akul Y Mehta,Kelsey M Charon et al.
Tianwei Jia et al.
Antibodies to carbohydrate antigens present in blood group substances and pathogens are important to human health, transplantation, and transfusion medicine. Identifying such antibodies typically requires complex technologies and instrument...