A synthetic biology roadmap for sustainable production of the plant-originated anti-cancer drug paclitaxel [0.03%]
可持续生产植物抗癌药物紫杉醇的人工合成生物学路线图
Chun-Lin Tan,Xin Yu,Hui-Cheng Feng et al.
Chun-Lin Tan et al.
Paclitaxel, a clinically potent anticancer drug derived from Taxus species, faces persistent challenges in sustainable supply. Synthetic biology presents substantial opportunities for its de novo production, particularly with recent breakth...
CRISPR/Cas strategies to enhance CAR T-cell function and persistence via metabolic reprogramming [0.03%]
基于代谢重编译的CRISPR/Cas策略增强CAR-T细胞功能和持久性
Margaret R Wang,Wenli Mu,Anjie Zhen et al.
Margaret R Wang et al.
While chimeric antigen receptor (CAR) T-cell therapy has become a standard of care in various blood cancers, its full curative potential for other diseases has yet to be maximized. One key limiting factor is progressive T-cell exhaustion an...
Pipeline and insulated dual-reporter system to predict and quantify strong terminators from RNA-seq datasets for metabolic engineering [0.03%]
基于RNA测序数据预测和量化强终止子的管道及绝缘双报告系统用于代谢工程
Yunhao Chen,Qiaoning He,Qiushi Ye et al.
Yunhao Chen et al.
The limited availability of genetic regulatory parts, especially terminators from non-model microorganisms, hampers precise gene regulation and the construction of efficient microbial cell factories. To address this problem, we developed a ...
Bioengineering of vascular macrodevices for transplantation of insulin-producing cells [0.03%]
血管宏观装置的生物工程化以移植胰岛素产生细胞
Mohammad Karami,Majid Halvaei,Roxana Royaei et al.
Mohammad Karami et al.
Type 1 diabetes (T1D) is caused by the autoimmune destruction of insulin-producing cells (IPCs), resulting in disruptions to blood glucose regulation. Cell therapy is an established, FDA-approved treatment for T1D. Incorporating IPCs into v...
Biofilms at work: what limits efficient consortia for industrial production? [0.03%]
生物被膜的应用：什么限制了工业生产的高效共生群落？
Sunday Olakunle Oguntomi,Alessandro Mattedi,Elia Marin et al.
Sunday Olakunle Oguntomi et al.
Biofilms, complex and structured microbial communities encased within extracellular polymeric substances, represent an emerging area of interest in bioprocesses for the production of value-added chemicals. The properties of biofilms offer p...
Exploring substrate cofeeding for enhanced acetogenic C1 bioconversion with AneVO, a low-cost anaerobic parallel bioreactor platform [0.03%]
利用廉价厌氧并行生物反应器平台AneVO探索底物共馈以增强乙酰ogens的C1生化转化性能
Kathryn O Hoyt,Guanyu Zhou,William Gasparrini et al.
Kathryn O Hoyt et al.
Acetogenic bacteria are attractive biocatalysts for biochemical production from sustainable single-carbon (C1) feedstocks. The major challenge is their energy-constrained anaerobic lifestyle, which results in slow growth and low productivit...
The landscape of ion-releasing biomaterials: from preclinical insights to clinical studies [0.03%]
离子释放生物材料的发展历程：从临床前研究到临床试验
Qilin Li,Shuo Huang,Ping Wu
Qilin Li
Recent advances in ion-releasing biomaterials have revealed transformative opportunities in clinical medicine. By leveraging the bioactive properties of ions, such as targeted immunomodulation, antimicrobial activity, and proregenerative ef...
Beatrice Bader,Maximillian Zinner,Hubert Trübel
Beatrice Bader
Biopharma start-ups drive pharmaceutical innovation, relying on local ecosystems that connect key actors, resources, and enabling factors. This article synthesizes literature and expert insights into a framework that outlines five pillars-n...
CRISPR as a next-generation environmental biosurveillance tool for air, land, and water [0.03%]
基于CRISPR的空地水环境监测技术
Benjamín Durán-Vinet,Jo-Ann L Stanton,Gert-Jan Jeunen et al.
Benjamín Durán-Vinet et al.
Clustered regularly interspaced short palindromic repeats (CRISPR)-based environmental biosurveillance (CRISPR-eBx) offers a portable, specific, sensitive, and cost-effective platform for detecting organisms from environmental nucleic acids...
Designing at-source and end-of-pipe biotechnologies to tackle pharmaceutical pollution [0.03%]
源头和末端医药污染生物治理技术的设计
Vladimir Akhrimenko,Klaus Kümmerer,Sixto Malato et al.
Vladimir Akhrimenko et al.
Pharmaceutical pollution, defined as the presence of antibiotics, antidepressants, antidiabetics, and other pharmaceuticals in the environment, is a ubiquitous problem. Active pharmaceutical ingredients (APIs), along with their metabolites ...