Extracellular vesicle manufacture via FACTORY: fully automated collection technology and optimum machinery for clinical translational applications [0.03%]
FACTORY：用于临床转化应用的全自动外泌体生产工艺和技术优化机器
Xing-Chi Liu,Jia-Wen Tian,Jing-Yi Xu et al.
Xing-Chi Liu et al.
Extracellular vesicles (EVs) hold significant potential as therapeutic agents and drug carriers. However, current isolation techniques severely limit their clinical application, due to heavy reliance on manual operation, making large-scale ...
Gas plasma technology mediates deep tissue and anticancer events independently of hydrogen peroxide [0.03%]
等离子体技术可独立于过氧化氢介导深层组织和抗肿瘤事件
Lea Miebach,Marten Hagge,Alice Martinet et al.
Lea Miebach et al.
Reactive oxygen species (ROS) can be used as anticancer agents. Some technologies, such as medical gas plasmas, generate large amounts and varieties of these mainly short-lived, reactive molecules. However, it is unclear how far reactive sp...
Zhaohui Qin,Zhaolong Deng,Chengwei Li et al.
Zhaohui Qin et al.
Artificial intelligence (AI) has revolutionized life sciences, driving transformative advances in engineering clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas)-based genome editors for therapeutic an...
Rui Li,Liuyan Gu,Lars M Blank et al.
Rui Li et al.
The important food microorganism Lactococcus lactis is limited by its fermentative metabolism and low energy yield. This limitation can be partially overcome by activating aerobic respiration which, in a food context, can be difficult to ac...
Functional substrate-enhanced bioprinting technology for next-generation organ-on-a-chip: from fabrication to functionalization [0.03%]
下一代器官芯片的功能底物增强生物打印技术：从制造到功能化
Gihyun Lee,Soo Jee Kim,Je-Kyun Park
Gihyun Lee
The integration of bioprinting with advanced substrate technologies offers a transformative approach to tissue engineering, providing vital insight into the development of complex organ-on-a-chip systems. Bioprinting enables the creation of...
Pushpendra K Gupta,Sourabh Kumar
Pushpendra K Gupta
Gene editing technologies have revolutionized the field of biotechnology. CRISPR-Cas methods using RNA-guided enzymes are the most used gene editing tools and have produced gene-edited crops (rice, wheat, corn, etc.) and human therapeutics ...
Protein-glycan engineering in vaccine design: merging immune mechanisms with biotechnological innovation [0.03%]
蛋白-糖工程在疫苗设计中的应用：免疫机制与生物技术创新的融合
Maxwell Kearns,Mengwan Li,Asher J Williams
Maxwell Kearns
Glycans are critical regulators of immune recognition, influencing pathogen detection and immune modulation. Despite their potential in vaccine design, challenges, such as glycan heterogeneity and immune evasion, persist. Recent advances in...
Organ-on-a-chip systems for modeling tumor and normal tissue microenvironments in radiotherapy research [0.03%]
放射治疗研究中用于模拟肿瘤和正常组织微环境的芯片器官系统
Rohollah Nasiri,Arnav Sankaranthi,Guillem Pratx
Rohollah Nasiri
Radiation therapy (RT) precisely targets tumors with ionizing radiation, aiming to achieve local control while minimizing collateral damage to surrounding healthy tissues. Radiation research is often carried out in animal models, but these ...
Advances and optimization strategies in prime editing of human pluripotent stem cells [0.03%]
人类多能干细胞prime编辑的研究进展与优化策略
Heran Getachew,Thibaud Metais,Laurence Daheron et al.
Heran Getachew et al.
Prime editing, first introduced in 2019, is a precise and efficient genome-editing technique with applications across various organisms and cell lines, including human pluripotent stem cells (hPSCs). Despite its revolutionary potential, pri...
Madoka Nagata,Ellie D Wilson,Kazunori Ikebukuro et al.
Madoka Nagata et al.
Therapeutic monoclonal antibodies (mAbs) exhibit significant interindividual pharmacokinetic (PK) variability, necessitating therapeutic drug monitoring (TDM). However, current monitoring methods require complex and time-consuming laborator...