Alex B Lu,Anna C F Lewis
Alex B Lu
A common framing for governing artificial intelligence (AI) in the biological sciences is to focus on risk mitigation owing to the technology's potential 'dual-use' for both beneficial and harmful applications. This is a reactive policy app...
Farhad Nazarian-Firouzabadi,Jianing Bai,Cesar de la Fuente-Nunez
Farhad Nazarian-Firouzabadi
The discovery and manipulation of upstream open reading frames (uORFs) represent a promising frontier in plant biotechnology, offering strategies to enhance disease resistance and crop resilience. Here, we explore the role of uORFs in regul...
Bioinspired thermoreversible bioink orchestrates focal adhesion-dependent osteogenesis [0.03%]
受生物启发的热可逆性生物墨水调控焦粘附依赖性成骨分化
Tanmay Gupta,Pritish Rath,Viktoriya Pakharenko et al.
Tanmay Gupta et al.
Synergistic integration of bone extracellular matrix (bECM) macromolecules in biomimetic bone tissue engineering (BTE) remains underexplored. This study presents a novel bioink for load-bearing 3D bioprinting (LB-3DBP), comprising gelatin a...
How a kidney microenvironment atlas can advance kidney tissue engineering [0.03%]
肾微环境图谱在肾脏组织工程中的应用展望
Jim Koldenhof,Marianne C Verhaar,Rosalinde Masereeuw et al.
Jim Koldenhof et al.
Despite advances in cellular knowledge through kidney cell and protein atlases, tissue-engineered kidney models remain functionally incomplete. A major gap lies in our limited knowledge of the extracellular matrix (ECM) and the mechanical p...
Preeti Patel,Dehua Pei,Guo-Liang Wang
Preeti Patel
Nanobodies (Nbs) offer high potency, specificity, stability, and engineering versatility. Although well established in biomedicine, their use in crop protection is only emerging. In this forum, we summarize key advances in Nb-based immune r...
Mahmoud Tavakoli,Lixin Zong,Linwei She et al.
Mahmoud Tavakoli et al.
Carbon dots (CDs) have broad applications across life sciences. This forum highlights the most recent breakthroughs of CDs in plant genomics and epigenomics, including gene transcription, their roles as carriers for delivering DNA, RNA, and...
Brown adipose tissue engineering: advances, challenges, and future directions [0.03%]
棕色脂肪组织工程：进展、挑战与未来方向
Aslı Sena Karanfil,Fiona Louis,Michiya Matsusaki
Aslı Sena Karanfil
Obesity is a major health issue as it increases the risk of developing chronic diseases, including cardiovascular disorders, diabetes, and certain types of cancer. Brown adipose tissue (BAT) is a promising target for obesity treatment due t...
Microalgae-made biopharmaceuticals and their potential role in the One Health approach [0.03%]
微藻制造的生物药及其在大健康理念中的潜在作用
Ileana García-Silva,Sornkanok Vimolmangkang,Sergio Rosales-Mendoza
Ileana García-Silva
Biopharmaceuticals play a crucial role in the One Health approach by providing preventive and therapeutic solutions that support both human and animal health. The microalgae-based platform for producing biopharmaceuticals offers low product...
Rational bioengineering of polysaccharide in designing of microbiome modulation [0.03%]
理性工程技术助力多糖设计及微生态调节功能研究
Jeong Hyun Moon,Kidong Kim,Yubin Kim et al.
Jeong Hyun Moon et al.
Targeted modulation of the gut microbiome offers significant promise for preventing and treating diverse diseases; yet, enhancing the efficacy of these interventions remains challenging. Polysaccharides have emerged as potent microbiome mod...
Virus-like particles as modular interfaces for biomaterial functionalization [0.03%]
病毒样颗粒作为生物材料功能化的模块化界面
Hasna Maayouf,Rayane Hedna,Alphonse Boché et al.
Hasna Maayouf et al.
Biomaterial surface biofunctionalization refers to the process of modifying a biomaterial's surface to improve its interaction with biological systems. Controlling cell-material interactions is crucial, but current methods using native extr...