Ethical and legal considerations of digital animal models: pioneering reduction and replacement [0.03%]
数字动物模型的伦理和法律考量：开创性的减少和替代方法
Federico Germani,Julian W März,Alessandro Luciani et al.
Federico Germani et al.
The development of digital animal models represents a promising avenue for advancing the ethical principles of reduction and replacement in biomedical research. This paper discusses the potential of models built upon artificial intelligence...
Food production from air: gas precision fermentation with hydrogen-oxidising bacteria [0.03%]
空气造食品：产氢菌精密发酵技术
Margarita Bernal-Cabas,Karan Kumar,Owen Terpstra et al.
Margarita Bernal-Cabas et al.
The breach of six planetary boundaries highlights the need for sustainable food production. Aerobic hydrogen-oxidising bacteria (HOBs) convert atmospheric CO2 and green hydrogen (H2) into biomass via gas fermentation, a process already used...
Carl Holt
Carl Holt
A key step in the precision fermentation of casein proteins is correct phosphorylation to generate one or more short linear sequence motifs (SLiMs) containing three or more phosphorylated seryl residues. The work of Balasubramanian et al. t...
Metabolic and immunomodulatory control of type 2 diabetes via generating cellular itaconate reservoirs by inflammatory-targeting gene-therapy nanovesicles [0.03%]
通过炎症靶向基因治疗纳米囊泡生成细胞衣康酸库以代谢和免疫调节控制2型糖尿病
An Lao,Weiqi Li,Yiting Sun et al.
An Lao et al.
Type 2 diabetes (T2D) is characterized by persistent and unresolved tissue inflammation caused by the infiltration and dysregulation of immune cells. Current therapeutics targeting inflammatory immune cells for T2D remain limited. In this s...
Flying seed-inspired sensors for remote environmental monitoring on Earth and beyond [0.03%]
受会飞的种子启发的传感器用于地球及外太空远距离环境监测
Sagar Arya,Lukáš Spíchal,Radek Zbořil
Sagar Arya
Exploring mobility beyond traditional robotic systems such as walking, swimming, and jumping, flight through dispersal, gliding, or hovering remains an untapped frontier for advanced stimulus-responsive and -sensing materials. Nature-inspir...
Engineering chimeric signaling proteins for microbial whole-cell biosensors: from design to deployment [0.03%]
用于微生物全细胞生物传感器的嵌合信号蛋白的工程设计及应用
Güniz Özer Bergman,Sonia Mecacci,Vitor A P Martins Dos Santos et al.
Güniz Özer Bergman et al.
Microbial whole-cell biosensors (MWCBs) harness living cells to detect analytes and produce measurable outputs, enabling continuous, low-cost, and in situ sensing. Central to MWCB function are modular sensing architectures, which can be rep...
Development of a high-efficiency N-acetylneuraminic acid production platform through multi-pathway synergistic engineering [0.03%]
通过多途径协同改造构建高效生产神经氨酸平台技术
Guozhen Ma,Xiaolong Jiang,Bin Yang et al.
Guozhen Ma et al.
The growing demand for N-acetylneuraminic acid (NeuAc) has driven the need for efficient and environmentally sustainable biomanufacturing processes. Microbial fermentation offers a promising route, yet optimizing cell factories with excelle...
Membrane-targeted DNA frameworks with biodegradability recover cellular function and morphology from frozen cells [0.03%]
针对膜的可生物降解DNA框架从冻存细胞中恢复细胞功能和形态
Yedam Lee,Woo Hyuk Jung,Kyounghwa Jeon et al.
Yedam Lee et al.
Cell freezing is critical for the long-term preservation of biological materials, but is limited by the cytotoxicity and inefficacy of conventional cryoprotective agents, such as dimethyl sulfoxide (DMSO). Here, we introduce DNA frameworks ...
Targeting RAS-mutant cancer cells using a synthetic RAS-activated cancer killing system [0.03%]
利用合成RAS激活的癌症杀伤系统靶向RAS突变型癌细胞
Fei Teng,Qingqin Gao,Li Zhou et al.
Fei Teng et al.
Despite being the most commonly mutated proteins in cancer, oncogenic RAS proteins remain largely untapped as pharmacological targets. Here, we report a synthetic cancer-killing platform, termed 'RAS-activated cancer killing (RACK)' system....
Biomechanics in miniature: microfluidic-based in vitro modeling to decipher mechanobiological phenomena [0.03%]
微尺度生物力学：基于微流控的体外模型解析力学生物学现象
Hye Jin Hong,Na-Hyun Lee,Hye Sung Kim et al.
Hye Jin Hong et al.
Mechanobiology is a rapidly advancing field, offering innovative insights and therapeutic strategies for a range of pathophysiological conditions. Central to this progress is the ability to replicate complex cellular and tissue microenviron...