Deborah C I Goberdhan,Adrian L Harris,Clive Wilson
Deborah C I Goberdhan
Exosomes are formally defined as extracellular vesicles, which are formed in compartments with endosomal origin by the inward budding of the endosomal limiting membrane. Recent analyses of the dynamic events within exosome-generating compar...
Jenny Jin,Jiachen Hu,Mingyue Li et al.
Jenny Jin et al.
Ferroptosis is a cell death process defined by the iron-mediated peroxidation of membrane phospholipids that overwhelms the cell's innate antioxidant capabilities. Sitting at the nexus of iron, lipid, reactive oxygen species stress response...
Jingdai Zhang,Xiaohang Liu,Guo-Ping Shi et al.
Jingdai Zhang et al.
Eosinophils participate in immune regulation through their granule proteins and cytokines. Recent studies demonstrate eosinophil functional versatility through the mechanism of eosinophil extracellular traps (EETs). EET formation occurs via...
Yang Yu,Jing Zhuang,Changgang Sun
Yang Yu
T cell exhaustion represents a major barrier to the efficacy of cancer immunotherapy, driven by complex transcriptional reprogramming, epigenetic remodeling, and metabolic imbalance. Cheng et al. report in Nature that the E3 ubiquitin ligas...
Hui Zhang,Xiaojun Cai,Quazi T H Shubhra
Hui Zhang
By uncovering a lipid droplet (LD) quality-control pathway driven by ferroptosis suppressor protein 1, Lange et al. show that neutral-lipid oxidation shapes ferroptosis vulnerability. This work expands ferroptosis regulation beyond membrane...
Tore Skotland,Kirsten Sandvig
Tore Skotland
Biological membranes consist of a lipid bilayer with a highly asymmetric distribution of lipids in the two leaflets. This asymmetry is maintained by enzymes whose activities depend on cytosolic ATP and Ca2+ concentrations. Recently, a new m...
Leonardo Luis Artico,Sophia Hakam,Güneş Parlakgül et al.
Leonardo Luis Artico et al.
The endoplasmic reticulum (ER) is a central hub for essential cellular processes, including lipid and glucose metabolism, protein folding, calcium homeostasis, and detoxification. The ER exhibits a complex architecture, comprising multiple ...
Yu-Lu Cao,Chao-Pin Yang,Birong Shen et al.
Yu-Lu Cao et al.
Although cancer treatment has improved, many patients exhibit limited responses due to the intrinsic heterogeneity and adaptability of tumors, coupled with immunosuppressive conditions in the tumor microenvironment (TME). Mitochondrial dyna...
Deciphering the significance of p53 mutant proteins: (Trends Cell Biol. 2025 Mar;35(3):258-268) [0.03%]
Alessio Butera,Ivano Amelio
Alessio Butera
Published Erratum
Trends in cell biology. 2026 Apr 1:S0962-8924(26)00002-4. DOI:10.1016/j.tcb.2026.01.002 2026
Cameron O Schmitz,Ankur Jain
Cameron O Schmitz
How do single cells weigh conflicting internal and external signals to arrive at unambiguous fate decisions? Peskett et al. reveal that a partnership between two condensates, Whi3 assemblies and P-bodies, forms a decision module in budding ...