Soda Balla Diop,Rolf Bodmer
Soda Balla Diop
The high degree of genetic conservation between Drosophila melanogaster and mammals has helped to translate many important findings into new knowledge, and has led to better understanding of many biological processes in vertebrates. For ove...
Sander Kooijman,José K van den Heuvel,Patrick C N Rensen
Sander Kooijman
Brown adipose tissue (BAT) activation reduces body fat and metabolic disorders by the enhanced combustion of lipids and glucose into heat. The thermogenic activity of brown adipocytes is primarily driven by the sympathetic nervous system (S...
Ross D Feldman,Lee E Limbird
Ross D Feldman
Whether aldosterone activates the G-protein-coupled estrogen receptor (GPER) has been questioned, recently, in the name of Copernicus. However, for G-protein-coupled receptors (GPCRs) multiple hormone activators are common. Further, studies...
Emerging Functional Divergence of β-Arrestin Isoforms in GPCR Function [0.03%]
β-arrestin 同工型在GPCR功能中的新兴功能性分化
Ashish Srivastava,Bhagyashri Gupta,Charu Gupta et al.
Ashish Srivastava et al.
G protein-coupled receptors (GPCRs) are tightly regulated by multifunctional protein β-arrestins. Two isoforms of β-arrestin sharing more than 70% sequence identity and overall very similar 3D structures, β-arrestins 1 and 2, were origin...
Tuulia Hyötyläinen,Matej Orešič
Tuulia Hyötyläinen
Lipidomic analysis, which enables comprehensive characterization of molecular lipids in biological systems, is rapidly becoming an essential tool in biomedical research. While lipidomics already have contributed to several conceptual advanc...
Alessandra Chesi,Struan F A Grant
Alessandra Chesi
Obesity among children and adults has notably escalated over recent decades and represents a global major health problem. We now know that both genetic and environmental factors contribute to its complex etiology. Genome-wide association st...
Elizabeth A Schroeder,Anne Brunet
Elizabeth A Schroeder
Historically, fat was considered detrimental to health and lifespan. However, lipidomics, the quantification of all lipid molecules in a biological sample, and genetic studies in model organisms are revealing specific fats that may promote ...
Masayuki Saito,Takeshi Yoneshiro,Mami Matsushita
Masayuki Saito
Brown adipose tissue (BAT) is a site of adaptive non-shivering thermogenesis after cold exposure, and is involved in the regulation of energy expenditure and body fatness. BAT can be activated and recruited by not only cold exposure but als...
Silviu Sbiera,Timo Deutschbein,Isabel Weigand et al.
Silviu Sbiera et al.
Cushing's disease (CD) is caused by corticotropin-secreting pituitary adenomas and results in substantial morbidity and mortality. Its molecular basis has remained poorly understood until the past few years, when several proteins and genes ...
Mehboob A Hussain,Woo-Jin Song,Andrew Wolfe
Mehboob A Hussain
While kisspeptin was initially found to function as a metastasis suppressor, after identification of its receptor KISS1R and their expression profiles in tissues such as the hypothalamus and adrenals, kisspeptin and KISS1R were predominantl...