The 'Omics' of Voluntary Exercise: Systems Approaches to a Complex Phenotype [0.03%]
“组学”视角下的自主运动研究——探究复杂表型的系统方法学 접근路径
Scott A Kelly,Fernando Pardo-Manuel de Villena,Daniel Pomp
Scott A Kelly
Predisposition to engage in exercise is highly variable and simultaneously influenced by the environment, complex genomics, and their interactions. Given the importance of exercise to health, understanding the underlying influences of varia...
Linking Microbiota to Human Diseases: A Systems Biology Perspective [0.03%]
从系统生物学角度研究微生物组与人类疾病之间的关系
Hao Wu,Valentina Tremaroli,Fredrik Bäckhed
Hao Wu
The human gut microbiota encompasses a densely populated ecosystem that provides essential functions for host development, immune maturation, and metabolism. Alterations to the gut microbiota have been observed in numerous diseases, includi...
Jeffrey M Zigman,Sebastien G Bouret,Zane B Andrews
Jeffrey M Zigman
Ghrelin is a metabolic hormone that promotes energy conservation by regulating appetite and energy expenditure. Although some studies suggest that antagonizing ghrelin function attenuates body weight gain and glucose intolerance on a high c...
Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins [0.03%]
代谢酶作为RNA结合蛋白的新搭档享受新的合作伙伴关系
Alfredo Castello,Matthias W Hentze,Thomas Preiss
Alfredo Castello
In the past century, few areas of biology advanced as much as our understanding of the pathways of intermediary metabolism. Initially considered unimportant in terms of gene regulation, crucial cellular fate changes, cell differentiation, o...
Transcriptional and Chromatin Regulation during Fasting - The Genomic Era [0.03%]
饥饿状态下的转录和染色质调控——基因组时代
Ido Goldstein,Gordon L Hager
Ido Goldstein
An elaborate metabolic response to fasting is orchestrated by the liver and is heavily reliant on transcriptional regulation. In response to hormones (glucagon, glucocorticoids) many transcription factors (TFs) are activated and regulate va...
Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation [0.03%]
蛋白质磷酸化：代谢调节的主要开关机制
Sean J Humphrey,David E James,Matthias Mann
Sean J Humphrey
Metabolism research is undergoing a renaissance because many diseases are increasingly recognized as being characterized by perturbations in intracellular metabolic regulation. Metabolic changes can be conferred through changes to the expre...
Athanasios Fountas,Leonidas-Nikolaos Diamantopoulos,Agathocles Tsatsoulis
Athanasios Fountas
Deregulation of protein tyrosine kinase (PTK) activity is implicated in various proliferative conditions. Multi-target tyrosine kinase inhibitors (TKIs) are increasingly used for the treatment of different malignancies. Recently, several cl...
Sean M Hartig,Mark P Hamilton,David A Bader et al.
Sean M Hartig et al.
Global expression analyses demonstrate that alterations in miRNA levels correlate with various metabolic diseases. miRNAs regulate central metabolic pathways and thus play vital roles in maintaining organismal energy balance and metabolic h...
Jeffrey M Peters,Frank J Gonzalez,Rolf Müller
Jeffrey M Peters
The role of the nuclear hormone receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in carcinogenesis is controversial because conflicting studies indicate that it both inhibits and promotes tumorigenesis. In this review, ...
FGF21 Revolutions: Recent Advances Illuminating FGF21 Biology and Medicinal Properties [0.03%]
FGF21革命：近期进展揭示FGF21生物学及药用属性
Alexei Kharitonenkov,Richard DiMarchi
Alexei Kharitonenkov
The biology of fibroblast growth factor 21 (FGF21) has evolved through its first decade at a revolutionary pace with dramatic refinements in this relatively short span of time. This field is poised now with a deeper understanding of its spe...