Amir Zarrinpar,Amandine Chaix,Satchidananda Panda
Amir Zarrinpar
Cyclical expression of cell-autonomous circadian clock components and key metabolic regulators coordinate often discordant and distant cellular processes for efficient metabolism. Perturbation of these cycles, either by genetic manipulation...
George N Ioannou
George N Ioannou
Lipotoxicity drives the development of progressive hepatic inflammation and fibrosis in a subgroup of patients with nonalcoholic fatty liver disease (NAFLD), causing nonalcoholic steatohepatitis (NASH) and even progression to cirrhosis and ...
Jingyi Chi,Paul Cohen
Jingyi Chi
The PRDM [PRDI-BFI (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1) homologous domain containing] protein family is involved in a spectrum of biological processes including cel...
Henry J Pownall,Antonio M Gotto Jr
Henry J Pownall
Although high-density lipoprotein-cholesterol (HDL-C) concentration is a negative risk factor for atherosclerotic cardiovascular disease (CVD), efforts to reduce CVD risk by raising HDL-C have not been uniformly successful. Many studies hav...
Wei-Jen Tang
Wei-Jen Tang
Insulin-degrading enzyme (IDE) selectively degrades peptides, such as insulin, amylin, and amyloid β (Aβ) that form toxic aggregates, to maintain proteostasis. IDE defects are linked to the development of type 2 diabetes mellitus (T2DM) a...
Ilja L Kruglikov,Philipp E Scherer
Ilja L Kruglikov
Dermal white adipose tissue (dWAT) has received little appreciation in the past as a distinct entity from the better recognized subcutaneous white adipose tissue (sWAT). However, recent work has established dWAT as an important contributor ...
Emerging Technologies and their Applications in Lipid Compartment Measurement [0.03%]
新兴技术及其在脂质区室测量中的应用
Steven B Heymsfield,Houchun Harry Hu,Wei Shen et al.
Steven B Heymsfield et al.
Non-Communicable diseases (NCDs), including obesity, are emerging as the major health concern of the 21st century. Excess adiposity and related NCD metabolic disturbances have stimulated development of new lipid compartment measurement tech...
Susanne Mandrup
Susanne Mandrup
Biljana Atanasovska,Vinod Kumar,Jingyuan Fu et al.
Biljana Atanasovska et al.
Cardiometabolic diseases represent a common complex disorder with a strong genetic component. Currently, genome-wide association studies (GWAS) have yielded some 755 single-nucleotide polymorphisms (SNPs) encompassing 366 independent loci t...
Rachel V Richardson,Emma J Batchen,Martin A Denvir et al.
Rachel V Richardson et al.
The efficacy of mineralocorticoid receptor (MR) antagonism in the treatment of certain patients with heart failure has highlighted the pivotal role of aldosterone and MR in heart disease. The glucocorticoid (GC) receptor (GR) is also expres...