Daniel Pipeleers,Bart Keymeulen
Daniel Pipeleers
A recent study reported that encapsulation of human embryonic stem cell (hESC)-derived beta cells by a novel alginate formula protects against foreign body reactivity in immune-competent mice. Intraperitoneal implants corrected a diabetic s...
Akash Kumar Kaushik,Arun Sreekumar
Akash Kumar Kaushik
Molecular features of castration-resistant neuroendocrine prostate cancer (CRPC-NE) are not well characterized. A recent study that investigated genomic aberrations of CRPC-NE tumors suggests their clonal evolution from CRPC adenocarcinoma....
Jin Zhou,Bin Liu,Chun Liang et al.
Jin Zhou et al.
Skeletal muscle wasting occurs in a variety of diseases including diabetes, cancer, Crohn's disease, chronic obstructive pulmonary disease (COPD), disuse, and denervation. Tumor necrosis factor α (TNF-α) is involved in mediating the wasti...
Unraveling the Effects of PPARβ/δ on Insulin Resistance and Cardiovascular Disease [0.03%]
探究PPARβ/δ对胰岛素抵抗及心血管疾病影响的作用机制
Manuel Vázquez-Carrera
Manuel Vázquez-Carrera
Insulin resistance precedes dyslipidemia and type 2 diabetes mellitus (T2DM) development. Preclinical evidence suggests that peroxisome proliferator-activated receptor (PPAR) β/δ activators may prevent and treat obesity-induced insulin re...
Rashid K Sayyid,Neil E Fleshner
Rashid K Sayyid
Type 2 diabetes mellitus (T2DM) is a growing epidemic associated with many adverse complications. Urological complications of diabetes mellitus in men are gaining recognition. Previously unknown associations between T2DM and risk for prosta...
Nicoleta Cristina Olarescu,Jens Bollerslev
Nicoleta Cristina Olarescu
Adipose tissue (AT) is recognized as key contributor to the systemic insulin resistance and overt diabetes seen in metabolic syndrome. Acromegaly is a disease characterized by excessive secretion of growth hormone (GH) and insulin-like grow...
David J Friedman,Martin R Pollak
David J Friedman
Genetic variants in the Apolipoprotein L1 (APOL1) gene cause high rates of kidney disease in African Americans. These variants, found only in individuals with recent African ancestry, confer enhanced innate immunity against African trypanos...
Joanna Mattis,Amita Sehgal
Joanna Mattis
Sleep-wake cycles are known to be disrupted in people with neurodegenerative disorders. These findings are now supported by data from animal models for some of these disorders, raising the question of whether the disrupted sleep/circadian r...
Matthew J Schiewer,Karen E Knudsen
Matthew J Schiewer
DNA damage response and repair (DDR) is a tightly controlled process that serves as a barrier to tumorigenesis. Consequently, DDR is frequently altered in human malignancy, and can be exploited for therapeutic gain either through molecularl...
Metabolically Healthy Obesity: Personalised and Public Health Implications [0.03%]
代谢健康型肥胖：个性化与公共卫生的影响
Catherine M Phillips
Catherine M Phillips
Obesity is a heterogeneous condition; thus, metabolic abnormalities and cardiometabolic risk vary among obese individuals, with a significant proportion considered to be metabolically healthy. However, whether these individuals are truly he...