Giulia Cantini,Edoardo Mannucci,Michaela Luconi
Giulia Cantini
The incretin hormone glucagon-like peptide-1 (GLP-1) binds to and activates its G-protein-coupled-receptor GLP-1R to reduce glycaemia through the stimulation of insulin and suppression of pancreatic glucagon secretion. Recently, GLP-1 effec...
Elena Loche,Susan E Ozanne
Elena Loche
Obesity and its related metabolic comorbidities can be inherited across generations through non-genetic mechanisms. In a recent report, Huypens et al., using an in vitro fertilization approach, provide evidence that exposure to a high-fat d...
Circadian System and Glucose Metabolism: Implications for Physiology and Disease [0.03%]
昼夜系统与葡萄糖代谢：对生理学和疾病的影响
Jingyi Qian,Frank A J L Scheer
Jingyi Qian
The circadian system serves one of the most fundamental properties present in nearly all organisms: it generates 24-h rhythms in behavioral and physiological processes and enables anticipating and adapting to daily environmental changes. Re...
Fernando Rivadeneira,Outi Mäkitie
Fernando Rivadeneira
Genomic technologies have evolved rapidly contributing to the understanding of diseases. Genome-wide association studies (GWAS) and whole-exome sequencing have aided the identification of the genetic determinants of monogenic and complex co...
The Fiber Gap and the Disappearing Gut Microbiome: Implications for Human Nutrition [0.03%]
消失的肠道微生物组及其对人类营养的影响
Edward C Deehan,Jens Walter
Edward C Deehan
Increasing evidence indicates that modern lifestyle, and specifically a Western diet, has led to a substantial depletion of the human gut microbiome. This loss is implicated in the rampant increase of chronic diseases, providing an incentiv...
Celine E Riera,Andrew Dillin
Celine E Riera
Sensory perception comprises gustatory (taste) and olfactory (smell) modalities as well as somatosensory (pain, heat, and tactile mechanosensory) inputs, which are detected by a multitude of sensory receptors. These sensory receptors are co...
Eva Tudurí,Miguel López,Carlos Diéguez et al.
Eva Tudurí et al.
Glucagon-like peptide 1 (GLP-1) exerts many actions that improve glycemic control. GLP-1 stimulates glucose-stimulated insulin secretion and protects β cells, while its extrapancreatic effects include cardioprotection, reduction of hepatic...
Cuiying Xiao,Marc L Reitman
Cuiying Xiao
Bombesin-like receptor 3 (BRS-3) is an X-linked orphan Gq-coupled receptor that regulates food intake, metabolic rate, body temperature, heart rate, blood pressure, and insulin secretion. Most BRS-3 actions occur via the brain, through mech...
Human Beige Adipocytes: Epiphenomenon or Drivers of Metabolic Improvements? [0.03%]
人类 beige 脂肪细胞：代谢改善的附带现象还是驱动因素？
Qiong A Wang,Philipp E Scherer
Qiong A Wang
There is a lack of direct evidence that human brown or beige adipocytes improve whole-body energy homeostasis. In a recent study, Min et al. implanted proliferated human adipocyte progenitors from a 3D culture system in mice. Implants respo...
Amandine Chaix,Satchidananda Panda
Amandine Chaix
Food-seeking activity at a predictable time of the day is one of the fundamental 'opportunistic behaviors' for survival. The neural and molecular basis for such anticipatory activity is not clearly understood. However, a new report shows th...