Sadhbh O&#x;Neill,Mette Bohl,Soren Gregersen et al.
Sadhbh O&#x;Neill et al.
Metabolic syndrome (MetS) is a constellation of factors increasing the risk of type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and cancer. MetS diagnosis is cumbersome and the precise diagnosis differs throughout the world. E...
Laetitia Koppe,Vincent Poitout
Laetitia Koppe
The factors that precipitate the transition from insulin resistance to type 2 diabetes mellitus (T2DM) remain elusive. A recent study showed that circulating levels of the furan fatty acid (FA) metabolite 3-Carboxy-4-Methyl-5-Propyl-2-Furan...
Gregor Reid
Gregor Reid
The microbiome of the vagina has universal traits that override race, diet, lifestyle, and socioeconomic status. While five community state types have been proposed, the actual number is likely closer to ten. Nevertheless, while lactobacill...
David R Clemmons
David R Clemmons
Insulin-like growth factors (IGFs) circulate in extracellular fluids bound to a family of binding proteins. Although they function in a classical manner to limit the access of the IGFs to their receptors they also have a multiplicity of act...
Steven A Brown
Steven A Brown
The circadian clock directs nearly all aspects of diurnal physiology, including metabolism. Current research identifies several major axes by which it exerts these effects, including systemic signals as well as direct control of cellular pr...
Rebecca Courtney,Gary E Landreth
Rebecca Courtney
Liver X receptors (LXRs) are master regulators of cholesterol homeostasis and inflammation in the central nervous system (CNS). The brain, which contains a disproportionately large amount of the body's total cholesterol (∼25%), requires a ...
Correction to 'Obesity Impairs the Action of the Neuroendocrine Ghrelin System': [Trends in Endocrinology and Metabolism, 27 (2016) 54-63] [0.03%]
有关“肥胖损害神经内分泌胃泌素系统作用”的改正: [《内分泌学与代谢趋势》, 27 (2016) 54-63]
Jeffrey M Zigman,Sebastien G Bouret,Zane B Andrews
Jeffrey M Zigman
Erica L Scheller,William P Cawthorn,Aaron A Burr et al.
Erica L Scheller et al.
Marrow adipose tissue (MAT) is a unique fat depot, located in the skeleton, that has the potential to contribute to both local and systemic metabolic processes. In this review we highlight several recent conceptual developments pertaining t...
Neoantigens and Microenvironment in Type 1 Diabetes: Lessons from Antitumor Immunity [0.03%]
自身免疫性糖尿病中的新抗原和微环境：来自抗肿瘤免疫的启示
Maria J L Kracht,Arnaud Zaldumbide,Bart O Roep
Maria J L Kracht
Type 1 diabetes (T1D) is characterized by the selective and progressive destruction of insulin-producing beta cells by the immune system. An incomplete thymic selection against self-reactive islet antigens partly explains how these T cells ...
SCFA Receptors in Pancreatic β Cells: Novel Diabetes Targets? [0.03%]
肠道菌群的短链脂肪酸与胰岛β细胞上的G蛋白偶联受体：糖尿病的新靶标？
Medha Priyadarshini,Barton Wicksteed,Gary E Schiltz et al.
Medha Priyadarshini et al.
Nutrient sensing receptors are key metabolic mediators of responses to dietary and endogenously derived nutrients. These receptors are largely G-protein-coupled receptors (GPCRs) and many are gaining significant interest as drug targets wit...