Josephine M Forbes
Josephine M Forbes
A recent study has highlighted the relationship between mitochondrial ATP generation and protection against organ injury following ischaemia-reperfusion injury in the kidney. Kidneys are fuel-hungry organs and only second to the heart in mi...
Christopher M Henstridge,Andrew J Brown,Maria Waldhoer
Christopher M Henstridge
Since the discovery of the lysophospholipid-sensitive receptor GPR55, hopes have been raised that targeting this G protein-coupled receptor (GPCR) may represent a novel approach for the treatment of metabolic disorders. We discuss conflicti...
Samik Bindu,Vinodkumar B Pillai,Mahesh P Gupta
Samik Bindu
Cardiovascular diseases (CVDs) are expanding at an alarming rate and people's propensity to develop them increases with age. Growing evidence indicates that sirtuins play a pivotal role in regulating a multitude of age-related diseases. Sir...
Francesca D&#x;Addio,Paolo Fiorina
Francesca D&#x;Addio
Despite the relatively high frequency of gastrointestinal (GI) disorders in individuals with type 1 diabetes (T1D), termed diabetic enteropathy (DE), the pathogenic mechanisms of these disorders remain to be elucidated. While previous studi...
Loren G Fong,Stephen G Young,Anne P Beigneux et al.
Loren G Fong et al.
GPIHBP1, a GPI-anchored protein in capillary endothelial cells, is crucial for the lipolytic processing of triglyceride-rich lipoproteins (TRLs). GPIHBP1 shuttles lipoprotein lipase (LPL) to its site of action in the capillary lumen and is ...
Alexander P Rudecki,Sarah L Gray
Alexander P Rudecki
The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) mediates diverse physiology from neuroprotection to thermoregulation. PACAP is well established as a master regulator of the stress response, regulating psychologic...
Maria Razzoli,Alessandro Bartolomucci
Maria Razzoli
Obesity and metabolic diseases are linked to chronic stress and low socioeconomic status. The mechanistic link between stress and obesity has not been clarified, partly due to the inherent complexity exemplified by the bidirectional effect ...
Glucagon-Like Peptide-1 Receptor Agonists: Beta-Cell Protection or Exhaustion? [0.03%]
胰高糖素样肽-1受体激动剂：β细胞保护还是衰竭？
Daniël H van Raalte,C Bruce Verchere
Daniël H van Raalte
Glucagon-like peptide (GLP)-1 receptor agonists enhance insulin secretion and may improve pancreatic islet cell function. However, GLP-1 receptor (GLP-1R) agonist treatment may have more complex, and sometimes deleterious, effects on beta c...
Joseph V Virbasius,Michael P Czech
Joseph V Virbasius
Mitogen-activated kinase kinase kinase kinase 4 (Map4k4), originally identified in small interfering (si)RNA screens and characterized by tissue-specific gene deletions, is emerging as a regulator of glucose homeostasis and cardiovascular h...
Metabolic Actions of the Type 1 Cholecystokinin Receptor: Its Potential as a Therapeutic Target [0.03%]
胆囊收缩素受体1型的代谢作用及其作为治疗靶点的潜力
Laurence J Miller,Aditya J Desai
Laurence J Miller
Cholecystokinin (CCK) regulates appetite and reduces food intake by activating the type 1 CCK receptor (CCK1R). Attempts to develop CCK1R agonists for obesity have yielded active agents that have not reached clinical practice. Here we discu...