Hiroshi Tsuneki,Toshiyasu Sasaoka,Takeshi Sakurai
Hiroshi Tsuneki
Modern lifestyles prolong daily activities into the nighttime, disrupting circadian rhythms, which may cause sleep disturbances. Sleep disturbances have been implicated in the dysregulation of blood glucose levels and reported to increase t...
The Ca(2+)/Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft [0.03%]
Ca2+/钙调蛋白/钙调神经磷酸酶激酶激酶2轴：天然的代谢调控机制
Kathrina L Marcelo,Anthony R Means,Brian York
Kathrina L Marcelo
Calcium (Ca(2+)) is an essential ligand that binds its primary intracellular receptor calmodulin (CaM) to trigger a variety of downstream processes and pathways. Central to the actions of Ca(2+)/CaM is the activation of a highly conserved C...
Tatiana Moro,Scott M Ebert,Christopher M Adams et al.
Tatiana Moro et al.
Aging impairs skeletal muscle protein synthesis, leading to muscle weakness and atrophy. However, the underlying molecular mechanisms remain poorly understood. Here, we review evidence that mammalian/mechanistic target of rapamycin complex ...
Sukanya Raghuraman,Ida Donkin,Soetkin Versteyhe et al.
Sukanya Raghuraman et al.
Recent research developments have shed light on the risk factors contributing to metabolic complications, implicating both genetic and environmental factors, potentially integrated by epigenetic mechanisms. Distinct epigenetic changes in im...
Abdikarim Abdullahi,Marc G Jeschke
Abdikarim Abdullahi
The study of white adipose tissue (WAT) 'browning' has become a 'hot topic' in various acute and chronic metabolic conditions, based on the idea that WAT browning might be able to facilitate weight loss and improve metabolic health. However...
Mark A Herman,Varman T Samuel
Mark A Herman
Epidemiological studies link fructose consumption with metabolic disease, an association attributable in part to fructose-mediated lipogenesis. The mechanisms governing fructose-induced lipogenesis and disease remain debated. Acutely, fruct...
Neural Stem Cells and Nutrients: Poised Between Quiescence and Exhaustion [0.03%]
神经干细胞与营养：介于静息与耗竭之间
Virve Cavallucci,Marco Fidaleo,Giovambattista Pani
Virve Cavallucci
Adult neurogenesis initiated by neural stem cells (NSCs) contributes to brain homeostasis, damage repair, and cognition. Energy metabolism plays a pivotal role in neurogenic cell fate decisions regarding self-renewal, expansion and multilin...
Use of Designer G Protein-Coupled Receptors to Dissect Metabolic Pathways [0.03%]
使用设计型G蛋白偶联受体解析代谢途径
Jürgen Wess
Jürgen Wess
G protein-coupled receptors (GPCRs) regulate virtually all metabolic processes, including glucose and energy homeostasis. Recently, the use of designer GPCRs referred to as designer receptors exclusively activated by designer drug (DREADDs)...
Partial Epithelial-to-Mesenchymal Transition and Other New Mechanisms of Kidney Fibrosis [0.03%]
部分上皮间质转化及其他新的肾脏纤维化机制
Sara Lovisa,Michael Zeisberg,Raghu Kalluri
Sara Lovisa
Kidney fibrosis is the unavoidable consequence of chronic kidney disease irrespective of the primary underlying insult. It is a complex phenomenon governed by the interplay between different cellular components and intricate networks of sig...
Looking Beyond Structure: Membrane Phospholipids of Skeletal Muscle Mitochondria [0.03%]
结构之外：骨骼肌线粒体膜磷脂分子取向及排列的固态核磁共振研究
Timothy D Heden,P Darrell Neufer,Katsuhiko Funai
Timothy D Heden
Skeletal muscle mitochondria are highly dynamic and are capable of tremendous expansion to meet cellular energetic demands. Such proliferation in mitochondrial mass requires a synchronized supply of enzymes and structural phospholipids. Whi...