Yun-Zi Mao,Shi-Min Zhao
Yun-Zi Mao
Metabolites are donors of epigenetic modifications. Zhao et al. demonstrated that an ELMSAN1 regulated nuclear pyruvate dehydrogenase complex (nPDC) generates an independent nuclear acetyl-CoA pool dedicated to histone acetylation. Disrupti...
The interplay between organized lymphoid structures and thermogenic adipose tissue [0.03%]
组织淋巴结构与生热脂肪组织之间的相互作用
Francisco M Acosta,Johanna Örling,Marko Salmi et al.
Francisco M Acosta et al.
Advances in the immunometabolism field have shown that infiltrated immune cells play a pivotal role in the development and function of thermogenic adipose tissue (TAT), including brown and beige fat. However, scarce research has focused on ...
Contribution of metabolism-independent glucose sensing to metabolic homeostasis [0.03%]
代谢独立的葡萄糖感应在代谢稳态中的作用
Nadia Rashid,Kavaljit H Chhabra
Nadia Rashid
Glucose sensing and signaling are central to cellular metabolic machinery for the regulation of metabolic homeostasis. Glucose sensing has been almost always assumed to be coupled with glucose metabolism; however, recent findings have unrav...
Biliverdin reductase-A is a key modulator in insulin signaling and metabolism [0.03%]
黄素腺嘌呤二核苷酸还原酶A在胰岛素信号传导和代谢中起关键调节作用
Antonella Tramutola,Fabio Di Domenico,Marzia Perluigi et al.
Antonella Tramutola et al.
Biliverdin reductase-A (BVRA) is a pleiotropic enzyme traditionally known for its antioxidant role in the heme degradation pathway. Recent findings have redefined BVRA as a master regulator of insulin signaling, acting as a kinase, scaffold...
Andrea Dell&#x;Olio,Franco Biasioli,Vincenzo Fogliano et al.
Andrea Dell&#x;Olio et al.
The human gut microbiome is a complex microbial ecosystem which has a profound impact on host health and disease. The research focus in this area is rapidly moving from taxonomy to functionality, elucidating the biological role of small mol...
Miaochun Xu,Yang Yu,Canhui Cao
Miaochun Xu
Taurine is a conditionally essential amino acid with paradoxical roles in cancer, as both tumor and immune cells rely on it for vital functions. Here, we discuss the emerging context-dependent functions of taurine and propose therapeutic st...
Ibrahim H Ibrahim,Cheng-Han Lin,Ming Zhou et al.
Ibrahim H Ibrahim et al.
Over the past decade, our understanding of cancer metabolism has advanced significantly, revealing a complex and dynamic landscape of metabolic reprogramming that facilitates tumor progression and promotes therapeutic resistance. To survive...
David S Umbaugh,Anna Mae Diehl,Kuo Du
David S Umbaugh
Hepatocyte senescence is increasingly recognized as a key contributor to liver pathophysiology. While traditionally viewed as a state of permanent growth arrest, hepatocyte senescence is now understood to be more dynamic and potentially rev...
Glucagon receptor antagonism requires further mechanistic attention on α-cell physiology [0.03%]
胰高血糖素受体拮抗作用需要进一步关注α细胞生理学机制
Jianxin Jia,Zhehui Li,Liyuan Zhao et al.
Jianxin Jia et al.
Glucagon receptor (GCGR) antagonism improves glycemic control; however, it also brings adverse effects through unclear underlying mechanisms. Here, we summarize emerging findings about the impact of GCGR blockade on α cells and discuss the...
Spatiotemporal coordination between local flux and systemic homeostasis in the small intestine [0.03%]
小肠局部物质传输与全身稳态的时空协调关系研究
Jian Zhang,Siwen Zhang,Liheng Du et al.
Jian Zhang et al.
The small intestine has a pivotal role in nutrient absorption, host defense, and endocrine functions, with the maintenance of its homeostasis relying on the synergistic interplay of intrinsic and extrinsic factors. These encompass a highly ...