Christopher Lipina,Harinder S Hundal
Christopher Lipina
Regulated in development and DNA damage response 1 (REDD1) has been functionally linked to the control of diverse cellular processes due, at least in part, to its ability to repress mammalian or mechanistic Target of Rapamycin (mTOR) Comple...
ESR1-Amplification-Associated Estrogen Receptor α Activity in Breast Cancer [0.03%]
乳腺癌中由 ESR1 放大引起的雌激素受体α活性
Frederik Holst,Christian F Singer
Frederik Holst
Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis [0.03%]
鞘脂从头合成：心血管稳态的调节器
Linda Sasset,Yi Zhang,Teresa M Dunn et al.
Linda Sasset et al.
Sphingolipids (SL) are both fundamental structural components of the eukaryotic membranes and signaling molecules that regulate a variety of biological functions. The highly-bioactive lipids, ceramide and sphingosine-1-phosphate, have emerg...
Karen L Chen,Zeynep Madak-Erdogan
Karen L Chen
Recent advances have suggested that steroid hormones such as estrogens, and gut microbiota might synergize to influence obesity, diabetes, and cancer. We discuss recent knowledge of the interactions between estrogens and gut microbiota, and...
Rafael Moncada,Manuel F Landecho,Gema Frühbeck
Rafael Moncada
A Joint Statement endorsed by 45 international organizations, clinicians, and researchers indicating when to recommend or consider metabolic surgery in type 2 diabetes mellitus (T2DM) treatment has been recently published. These new guideli...
Iphigenia Tzameli
Iphigenia Tzameli
Opposite Regulation of Ghrelin and Glucagon-like Peptide-1 by Metabolite G-Protein-Coupled Receptors [0.03%]
代谢产物G蛋白偶联受体对 ghrelin 和 glucagon样肽-1的相反调节作用
M S Engelstoft,T W Schwartz
M S Engelstoft
Gut hormones send information about incoming nutrients to the rest of the body and thereby control many aspects of metabolism. The secretion of ghrelin and glucagon-like protein (GLP)-1, two hormones with opposite secretory patterns and opp...
Luigi Gnudi,Richard J M Coward,David A Long
Luigi Gnudi
Diabetes mellitus (DM) is the major cause of end-stage renal disease (ESRD) globally, and novel treatments are urgently needed. Current therapeutic approaches for diabetic nephropathy (DN) are focussing on blood pressure control with inhibi...
Leveraging Mechanisms Governing Pancreatic Tumorigenesis To Reduce Pancreatic Cancer Mortality [0.03%]
利用调控胰腺肿瘤发生的机制来降低胰腺癌死亡率
Timothy R Donahue,David W Dawson
Timothy R Donahue
Pancreatic ductal adenocarcinoma (PDA) is a devastating malignancy with limited and modest clinical treatments. High-throughput technologies and accurate disease models now provide a comprehensive picture of the diverse molecular signaling ...
Suowen Xu,Peter Bai,Zheng Gen Jin
Suowen Xu