Stefano Palomba,Jessica Daolio,Giovanni Battista La Sala
Stefano Palomba
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and affects fertility and pregnancy in cases of oligoanovulation. Ovulation induction is often used to treat anovulatory patients with PCOS,...
Mitochondrial Adaptation in Nonalcoholic Fatty Liver Disease: Novel Mechanisms and Treatment Strategies [0.03%]
非酒精性脂肪性肝病的线粒体适应：新机制和治疗策略
Nishanth E Sunny,Fernando Bril,Kenneth Cusi
Nishanth E Sunny
Nonalcoholic fatty liver disease (NAFLD) is prevalent in patients with obesity or type 2 diabetes. Nonalcoholic steatohepatitis (NASH), encompassing steatosis with inflammation, hepatocyte injury, and fibrosis, predisposes to cirrhosis, hep...
Genome-Wide Insights into the Development and Function of Thermogenic Adipocytes [0.03%]
全基因组视角下生热脂肪细胞的发育及功能初探
Anne Loft,Isabel Forss,Susanne Mandrup
Anne Loft
Brown and brown-like adipocytes are specialized adipocytes with a high capacity to convert metabolic energy to heat. This function is not only eminent in supporting organismal thermogenesis, but may also have potential in the fight against ...
Amylin and Leptin: Co-Regulators of Energy Homeostasis and Neuronal Development [0.03%]
酰胺激素和瘦素：能量平衡和神经发育的共调节器
Barry E Levin,Thomas A Lutz
Barry E Levin
While the regulation of energy homeostasis by amylin is already well-characterized, emerging data suggest that amylin is also crucial for the development of neural pathways in the hypothalamus and caudal hindbrain (area postrema, AP; nucleu...
Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation [0.03%]
氧化脂质和脂蛋白在炎症中的作用机制及其相关性研究
Yury I Miller,John Y-J Shyy
Yury I Miller
Oxidized low-density lipoprotein (OxLDL), which contains hundreds of different oxidized lipid molecules, is a hallmark of hyperlipidemia and atherosclerosis. The same oxidized lipids found in OxLDL are also formed in apoptotic cells, and ar...
Physiological Adaptations to Sugar Intake: New Paradigms from Drosophila melanogaster [0.03%]
果蝇对糖摄入的生理适应性：新的范例
Wen-Bin Alfred Chng,Ville Hietakangas,Bruno Lemaitre
Wen-Bin Alfred Chng
Sugars are important energy sources, but high sugar intake poses a metabolic challenge and leads to diseases. Drosophila melanogaster is a generalist fruit breeder that encounters high levels of dietary sugars in its natural habitat. Conseq...
Nathan J Pavlos,Peter A Friedman
Nathan J Pavlos
Emerging findings disclose unexpected components of G protein-coupled receptor (GPCR) signaling and cell biology. Select GPCRs exhibit classical signaling, that is restricted to cell membranes, as well as newly described persistent signalin...
Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes [0.03%]
胰高血糖素样肽-1与中枢/外周神经系统：糖尿病中的双向调节机制
Giovanna Muscogiuri,Ralph A DeFronzo,Amalia Gastaldelli et al.
Giovanna Muscogiuri et al.
Glucagon-like peptide-1 (GLP-1) is released in response to meals and exerts important roles in the maintenance of normal glucose homeostasis. GLP-1 is also important in the regulation of neurologic and cognitive functions. These actions are...
Carlos Sebastián,Raul Mostoslavsky
Carlos Sebastián
Glucose-derived acetyl-CoA levels directly impact histone acetylation, linking the energetic status of the cell to its epigenome. Two recent reports showed that other carbon sources can contribute to the acetyl-CoA pool used for histone ace...
Luisa Tasselli,Wei Zheng,Katrin F Chua
Luisa Tasselli
SIRT6, a member of the Sirtuin family of NAD+-dependent enzymes, has established roles in chromatin signaling and genome maintenance. Through these functions, SIRT6 protects against aging-associated pathologies including metabolic disease a...