Centrally Mediated Cardiovascular Actions of the Angiotensin II Type 2 Receptor [0.03%]
血管紧张素Ⅱ受体Ⅱ型的中枢介导的心血管作用
U Muscha Steckelings,Annette de Kloet,Colin Sumners
U Muscha Steckelings
Sustained increases in the activity of the sympathetic neural pathways that exit the brain and which increase blood pressure (BP) are a major underlying factor in resistant hypertension. Recently available information on the occurrence of a...
Vibeke Kruse,Ditte Neess,Nils J Færgeman
Vibeke Kruse
The skin is the largest sensory organ of the human body. The skin not only prevents loss of water and other components of the body, but also is involved in regulation of body temperature and serves as an essential barrier, protecting mammal...
Deepika Garg,Sinnie Sin Man Ng,K Maravet Baig et al.
Deepika Garg et al.
Progesterone is essential for pregnancy maintenance and menstrual cycle regulation. Hormone action has been primarily ascribed to the well-characterized classical signaling pathway involving ligand binding, activation of nuclear progesteron...
Emily A Day,Rebecca J Ford,Gregory R Steinberg
Emily A Day
The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic pathways and may have therapeutic importance for treating obesity, insulin resistance, type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), an...
Ayelet Erez,Ilana Kolodkin-Gal
Ayelet Erez
Bacteria in nature reside in organized communities, termed biofilms, which are composed of multiple individual cells adhering to each other. Similarly, tumors are a multicellular mass with distinct cellular phenotypes. Both tumors and biofi...
Stanley S Schwartz,Solomon Epstein,Barbara E Corkey et al.
Stanley S Schwartz et al.
Advances in understanding diabetes mellitus (DM) through basic and clinical research have helped clarify and reunify a disease state fragmented into numerous etiologies and subtypes. It is now understood that a common pathophysiology drives...
Tumour-Derived Human Growth Hormone As a Therapeutic Target in Oncology [0.03%]
肿瘤衍生的人类生长激素作为肿瘤学治疗靶点
Jo K Perry,Zheng-Sheng Wu,Hichem C Mertani et al.
Jo K Perry et al.
The growth hormone (GH) and insulin-like growth factor-1 (IGF1) axis is the key regulator of longitudinal growth, promoting postnatal bone and muscle growth. The available data suggest that GH expression by tumour cells is associated with t...
Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action [0.03%]
GLUT4囊泡运输的最新研究进展——胰岛素作用的重要环节
Javier R Jaldin-Fincati,Martin Pavarotti,Scott Frendo-Cumbo et al.
Javier R Jaldin-Fincati et al.
Glucose transport is rate limiting for dietary glucose utilization by muscle and fat. The glucose transporter GLUT4 is dynamically sorted and retained intracellularly and redistributes to the plasma membrane (PM) by insulin-regulated vesicu...
Gut Microbiota, Endocrine-Disrupting Chemicals, and the Diabetes Epidemic [0.03%]
肠道微生物群、干扰素和糖尿病流行病学
Ganesan Velmurugan,Tharmarajan Ramprasath,Mithieux Gilles et al.
Ganesan Velmurugan et al.
Diabetes is rapidly emerging as one of the biggest health concerns worldwide, with profound implications for disability, mortality, and costs. This suddenly escalating rate of diabetes correlates with global industrialization and the produc...
Pro- and Antiarrhythmic Actions of Sulfonylureas: Mechanistic and Clinical Evidence [0.03%]
磺脲类药物的促心律失常和抗心律失常作用：机制和临床证据
Charles E Leonard,Sean Hennessy,Xu Han et al.
Charles E Leonard et al.
Sulfonylureas are the most commonly used second-line drug class for treating type 2 diabetes mellitus (T2DM). While the cardiovascular safety of sulfonylureas has been examined in several trials and nonrandomized studies, little is known of...