Min Long,Xing Li,Li Li et al.
Min Long et al.
p62, a protein capable of binding both ubiquitin and autophagy substrates, is well established as a key regulator in cancer and neurodegenerative diseases. Recently, there has been accumulating evidence that p62 is also a pivotal regulator ...
Irinna Papangeli,Hyung J Chun
Irinna Papangeli
Elabela (ELA), the second peptide ligand for the apelin receptor, APLNR, was previously found in lower vertebrates to be crucial for endoderm and cardiac development. Two new studies report on the phenotypes of Ela null mice, ranging from d...
Lorea Valcarcel-Jimenez,Edoardo Gaude,Veronica Torrano et al.
Lorea Valcarcel-Jimenez et al.
Altered metabolism is a distinct feature of cancer cells. During transformation, the entire metabolic network is rewired to efficiently convert nutrients to biosynthetic precursors to sustain cancer cell growth and proliferation. Whilst the...
Lorea Valcarcel-Jimenez,Edoardo Gaude,Veronica Torrano et al.
Lorea Valcarcel-Jimenez et al.
Altered metabolism is a distinct feature of cancer cells. During transformation, the entire metabolic network is rewired to efficiently convert nutrients to biosynthetic precursors to sustain cancer cell growth and proliferation. Whilst the...
Xiao Tian,Andrei Seluanov,Vera Gorbunova
Xiao Tian
Aging is a global decline of physiological functions, leading to an increased susceptibility to diseases and ultimately death. Maximum lifespans differ up to 200-fold between mammalian species. Although considerable progress has been achiev...
New Insights into the Nuclear Imaging Phenotypes of Cluster 1 Pheochromocytoma and Paraganglioma [0.03%]
簇1型嗜铬细胞瘤和副神经节瘤核医学表型的新认识
David Taïeb,Karel Pacak
David Taïeb
Pheochromocytomas and paragangliomas (PPGLs) belong to the family of neural crest cell-derived neoplasms. In up to 70% of cases they are associated with germline and somatic mutations in 15 well-characterized PPGL driver or fusion genes. PP...
Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells [0.03%]
应对压力：正常细胞和恶性细胞中ATF4介导的压力反应调节
Inge M N Wortel,Laurens T van der Meer,Michael S Kilberg et al.
Inge M N Wortel et al.
Activating transcription factor 4 (ATF4) is a stress-induced transcription factor that is frequently upregulated in cancer cells. ATF4 controls the expression of a wide range of adaptive genes that allow cells to endure periods of stress, s...
John Tower
John Tower
Aging-related diseases show a marked sex bias. For example, women live longer than men yet have more Alzheimer's disease and osteoporosis, whereas men have more cancer and Parkinson's disease. Understanding the role of sex will be important...
Janina Tokarz,Mark Haid,Alexander Cecil et al.
Janina Tokarz et al.
The metabolome, although very dynamic, is sufficiently stable to provide specific quantitative traits related to health and disease. Metabolomics requires balanced use of state-of-the-art study design, chemical analytics, biostatistics, and...
Sergio Portal-Núñez,Aranzazu Mediero,Pedro Esbrit et al.
Sergio Portal-Núñez et al.
Denosumab (Dmab) is a humanized monoclonal antibody that blocks RANKL (receptor activator for nuclear factor κB ligand), thereby exerting a potent bone antiresorptive action. Dmab treatment leads to a dramatic and sustained increase in bon...