Ahmed Lawan,Anton M Bennett
Ahmed Lawan
The mitogen-activated protein kinases (MAPKs) participate in a multitude of processes that control hepatic metabolism. The liver regulates glucose and lipid metabolism, and under pathophysiological conditions such as obesity, type 2 diabete...
Francesc Villarroya,Aleix Gavaldà-Navarro,Marion Peyrou et al.
Francesc Villarroya et al.
Brown adipose tissue (BAT) is responsible for adaptive non-shivering thermogenesis. Moreover, brown fat secretes regulatory factors, so-called brown adipokines, that have autocrine, paracrine, and endocrine actions. Brown adipokines are eit...
Stefania Carobbio,Anne-Claire Guénantin,Antonio Vidal-Puig
Stefania Carobbio
Obesity is a major health problem without satisfactory pharmacological treatment. A promising strategy is to promote energy dissipation by activating brown/beige adipose tissue. However, for this strategy to succeed it requires improving th...
A Sweet Deal for Diabetes [0.03%]
糖尿病人的福音甜品
Matteo Villa,Jing Qiu,Erika L Pearce
Matteo Villa
Sugars have pathogenic roles in diabetes. In Nature Medicine, Zhang et al. revisit this dogma and show that mannose induces the generation of regulatory T (Treg) cells. The immunoregulatory effect of mannose not only prevented the onset of ...
'SNO'-Storms Compromise Protein Activity and Mitochondrial Metabolism in Neurodegenerative Disorders [0.03%]
'A型β淀粉样蛋白低聚体通过干扰蛋白质活性和线粒体代谢从而导致神经退行性疾病'
Tomohiro Nakamura,Stuart A Lipton
Tomohiro Nakamura
The prevalence of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), is currently a major public health concern due to the lack of efficient disease-modifying therapeutic options. Recent evidence su...
Bharath K Mani,Jeffrey M Zigman
Bharath K Mani
Ghrelin administration induces food intake and body weight gain. Based on these actions, the ghrelin system was initially proposed as an antiobesity target. Subsequent studies using genetic mouse models have raised doubts about the role of ...
Insights into Stearoyl-CoA Desaturase-1 Regulation of Systemic Metabolism [0.03%]
关于硬脂酰辅酶A去饱和酶-1调节全身代谢的洞见
Ahmed M ALJohani,Deeba N Syed,James M Ntambi
Ahmed M ALJohani
Stearoyl-coenzyme A desaturase 1 (SCD1) is a central regulator of fuel metabolism and may represent a therapeutic target to control obesity and the progression of related metabolic diseases including type 2 diabetes and hepatic steatosis. S...
Walter L Miller
Walter L Miller
Until the mid-1980s studies of steroidogenesis largely depended on identifying steroid structures and measuring steroid concentrations in body fluids. The molecular biology revolution radically revolutionized studies of steroidogenesis with...
Regulation of Mammalian 13-Subunit Cytochrome c Oxidase and Binding of other Proteins: Role of NDUFA4 [0.03%]
哺乳动物细胞色素c氧化酶的13亚基调控及其他蛋白结合：NDUFA4的作用
Bernhard Kadenbach
Bernhard Kadenbach
Cytochrome c oxidase (CcO) is the final oxygen accepting enzyme complex (complex IV) of the mitochondrial respiratory chain. In contrast to the other complexes (I, II, and III), CcO is highly regulated via isoforms for six of its ten nuclea...
Ceramides - Lipotoxic Inducers of Metabolic Disorders: (Trends in Endocrinology and Metabolism 26, 538-550; 2015) [0.03%]
代谢紊乱的脂毒性诱导者： ceramide（《内分泌学与代谢学趋势》26，538-550；2015）
Bhagirath Chaurasia,Scott A Summers
Bhagirath Chaurasia