Cholesterol Transport Revisited: A New Turbo Mechanism to Drive Cholesterol Excretion [0.03%]
胆固醇转运再探：一个新的加速机制促进胆固醇排泄
Jan Freark de Boer,Folkert Kuipers,Albert K Groen
Jan Freark de Boer
A fine-tuned balance between cholesterol uptake and excretion by the body is pivotal to maintain health and to remain free from the deleterious consequences of cholesterol accumulation such as cardiovascular disease. The pathways involved i...
Redox Functions of Heme Oxygenase-1 and Biliverdin Reductase in Diabetes [0.03%]
糖尿病中的血红素氧化酶-1和胆绿素还原酶的氧化还原功能
Luc Rochette,Marianne Zeller,Yves Cottin et al.
Luc Rochette et al.
In patients with diabetes, the hyperglycemia-driven excess generation of reactive oxygen species (ROS) induces oxidative stress (OS) in a variety of tissues. OS is closely associated with chronic inflammation and has a key role in the patho...
Molecular Regulation of Fatty Acid Oxidation in Skeletal Muscle during Aerobic Exercise [0.03%]
有氧运动期间骨骼肌脂肪酸氧化的分子调节机制研究进展
Anne-Marie Lundsgaard,Andreas Mæchel Fritzen,Bente Kiens
Anne-Marie Lundsgaard
This review summarizes how fatty acid (FA) oxidation is regulated in skeletal muscle during exercise. From the available evidence it seems that acetyl-CoA availability in the mitochondrial matrix adjusts FA oxidation to exercise intensity a...
Interacting Cancer Machineries: Cell Signaling, Lipid Metabolism, and Epigenetics [0.03%]
相互作用的癌症机器：细胞信号传导、脂质代谢和表观遗传学
Thomas W Grunt
Thomas W Grunt
Cancer-specific perturbations of signaling, metabolism, and epigenetics can be a cause and/or consequence of malignant transformation. Evidence indicates that these regulatory systems interact with each other to form highly flexible and rob...
Coordination or Coincidence? The Relationship between Prolactin and Gonadotropin Secretion [0.03%]
协同作用或偶然一致？催乳素与促性腺激素分泌的关系
David R Grattan
David R Grattan
A recent paper demonstrates that kisspeptin can stimulate the secretion of both prolactin and luteinizing hormone (LH). This provides novel insight into mechanisms that could account for previous observations of concordant patterns of secre...
Antonio Molinaro,Annika Wahlström,Hanns-Ulrich Marschall
Antonio Molinaro
Bile acids are endocrine molecules that in addition to facilitating the absorption of fat-soluble nutrients regulate numerous metabolic processes, including glucose, lipid, and energy homeostasis. The signaling actions of bile acids are med...
David W Dodington,Harsh R Desai,Minna Woo
David W Dodington
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is crucial for transducing signals from a variety of metabolically relevant hormones and cytokines including growth hormone, leptin, erythropoietin, IL4,...
Jolien Vandewalle,Astrid Luypaert,Karolien De Bosscher et al.
Jolien Vandewalle et al.
Glucocorticoids (GCs) have been used clinically for decades as potent anti-inflammatory and immunosuppressive agents. Nevertheless, their use is severely hampered by the risk of developing side effects and the occurrence of glucocorticoid r...
Wei-Jun Wei,Guo-Qiang Zhang,Quan-Yong Luo
Wei-Jun Wei
Postsurgical management of differentiated thyroid cancer in China has gained a great success in the last twenty years, but there are still gaps to be filled. Here, we briefly review the current status and also extend an outlook for future d...
AMP-Activated Protein Kinase Regulation of the NLRP3 Inflammasome during Aging [0.03%]
AMP活化的蛋白激酶在衰老过程中对NLRP3炎性小体的调控作用
Mario D Cordero,Matthew R Williams,Bernhard Ryffel
Mario D Cordero
The NLRP3 inflammasome has recently emerged as an unexpected marker of stress and metabolic risk and has also been implicated in the development of major aging-related diseases such as gout, type 2 diabetes, obesity, cancer, and neurodegene...