Lipids guide T cell antitumor immunity by shaping their metabolic and functional fitness [0.03%]
脂质通过塑造T细胞的代谢和功能适应性来引导其抗肿瘤免疫作用
Letizia Rumiano,Teresa Manzo
Letizia Rumiano
Lipids are metabolic messengers essential for energy production, membrane structure, and signal transduction. Beyond their recognized role, lipids have emerged as metabolic rheostats of T cell responses, with distinct species differentially...
Epigenetic inheritance of PCOS by developmental programming and germline transmission [0.03%]
表观遗传学继承在PCOS发病机制中的作用及机理研究进展
Elisabet Stener-Victorin,Qiaolin Deng
Elisabet Stener-Victorin
Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder, affecting approximately 11-13% of women of reproductive age. Women with PCOS experience a higher prevalence of infertility, pregnancy complications, and cardi...
Mengchun Hu,Yingying Qin,Xue Jiao
Mengchun Hu
Ferroptosis has been implicated in several reproductive disorders, but the underlying mechanisms remain unknown; thus, interventions targeting this pathway are lacking. Here we summarize the emerging findings on ferroptosis in reproductive ...
Morag J Young,Seamus Heanue,Monica Kanki et al.
Morag J Young et al.
Circadian rhythms are highly conserved biorhythms of ~24 h that govern many fundamental biological processes, including cardiovascular (CV) homeostasis. Disrupting the timing of cellular oscillators promotes cellular stress, and induction o...
More than carriers, orosomucoids are key metabolic modulators [0.03%]
载脂蛋白A-I和载脂蛋白A-IV：不仅仅是载体它们是关键的代谢调节因子
Mi Jeong Heo,Inyoung Cheon,Kang Ho Kim
Mi Jeong Heo
Orosomucoids (ORMs) have historically been considered as carriers involved in drug and lipid delivery. However, recent studies indicate ORM2 as a hepatokine involved in metabolic regulation. Here, we highlight the functions of ORM2 in contr...
Sonja Entringer,Gernot Desoye
Sonja Entringer
Perceived stress levels, prevalence of pregnancies complicated by metabolic disorders, and childhood obesity have been increasing steadily. We here propose a pathway integrating stress-responsive biological systems into the established effe...
Braeden T Charlton,Richie P Goulding,Richard T Jaspers et al.
Braeden T Charlton et al.
When acute SARS-CoV-2 infections cause symptoms that persist longer than 3 months, this condition is termed long COVID. Symptoms experienced by patients often include myalgia, fatigue, brain fog, cognitive impairments, and post-exertional m...
Nirmala Mouttoulingam,Soraya Taleb
Nirmala Mouttoulingam
Tryptophan (Trp) metabolism is linked to health and disease, with indoleamine 2,3-dioxygenase 1 (IDO) being a key enzyme in its breakdown outside the liver. This process produces metabolites that influence metabolic and inflammatory respons...
Inter-organ communication is a critical machinery to regulate metabolism and aging [0.03%]
器官间通讯是调节代谢和衰老的关键机制
Kyohei Tokizane,Shin-Ichiro Imai
Kyohei Tokizane
Inter-organ communication (IOC) is a complex mechanism involved in maintaining metabolic homeostasis and healthy aging. Dysregulation of distinct forms of IOC is linked to metabolic derangements and age-related pathologies, implicating thes...
Intracellular endothelial cell metabolism in vascular function and dysfunction [0.03%]
血管功能和功能障碍中的内皮细胞代谢
Kathryn M Citrin,Balkrishna Chaube,Carlos Fernández-Hernando et al.
Kathryn M Citrin et al.
Endothelial cells (ECs) form the inner lining of blood vessels that is crucial for vascular function and homeostasis. They regulate vascular tone, oxidative stress, and permeability. Dysfunction leads to increased permeability, leukocyte ad...