Yalan Deng,Zilong Zhao,Yutong Sun et al.
Yalan Deng et al.
The liver possesses a unique regenerative capacity, driven by mechanisms that extend beyond classical growth factor signaling. Recent studies underscore the importance of metabolic reprogramming, mitochondrial adaptation, and signaling meta...
Mitophagy in the adaptation to pancreatic β cell stress in diabetes [0.03%]
糖尿病状态下胰岛β细胞应激适应中的线粒体自噬作用
Elena Levi-D&#x;Ancona,Ava M Stendahl,Belle A Henry-Kanarek et al.
Elena Levi-D&#x;Ancona et al.
Mitophagy is a crucial quality control process that preserves metabolic efficiency by selectively targeting damaged mitochondria for removal. Given the high metabolic demand of pancreatic β cells' insulin secretion, disruption of mitophagy...
Methionine restriction and mimetics to ameliorate human aging and disease [0.03%]
蛋氨酸限制及模拟物在改善人类衰老及疾病方面的应用
Andrey A Parkhitko,Sudipta Pathak,Jay E Johnson et al.
Andrey A Parkhitko et al.
Methionine restriction (MetR) attenuates the severity of numerous age-related diseases and extends lifespan across multiple species. Implementing MetR in humans remains challenging due to the low palatability of MetR diets, unfavorable side...
Mohaned Benzarti,Elisabeth Letellier,Johannes Meiser
Mohaned Benzarti
Yiwei Zhu,Bishuang Cai
Yiwei Zhu
Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease posing a major global health concern, closely related to the rising prevalence of obesity. Liver fibrosis is the primary determinant of adverse outcomes ...
Rethinking 'normal': are pubertal milestones and growth charts obsolete? [0.03%]
“正常”的再思考：青春期成长发育指标过时了吗？
Balaji Chinnasami,Kanimozhi Sadasivam,Aamina Hussain
Balaji Chinnasami
Childhood development and pubertal milestones continue to be pillars of pediatric growth monitoring, but increasing trends in childhood obesity and precocious puberty indicate that existing 'normal' criteria may be misleading. Here, we sugg...
Cold-season programming reinforces the brown fat-cardiometabolic health link [0.03%]
寒冷季节编程强化褐色脂肪-心血管健康联系
Taylah L Gaynor,Camilla Scheele
Taylah L Gaynor
Recent work by Yoneshiro et al. links brown adipose tissue (BAT) activity to environmental temperatures during conception, highlighting intergenerational influences shaping BAT function. Here we explore how these findings translate into a c...
CD8+ T cell stressors converge on shared metabolic-epigenetic networks [0.03%]
胞因子信号转导受损的CD8+t细胞会引发代谢表观遗传网络异常并导致衰竭性反应
Yangtao Shangguan,Jianxiang Wang,Ping-Chih Ho et al.
Yangtao Shangguan et al.
CD8+ T cells are vital for antiviral and antitumor immunity, yet in hostile microenvironments, they experience metabolic stress, leading to mitochondrial damage, metabolic dysregulation, and chromatin remodeling that cause immune dysfunctio...
Hydroxyestradiol alleviates acute kidney injury via blockade of ferroptosis [0.03%]
羟基雌二醇通过抑制铁死亡来缓解急性肾损伤
Siyuan Zhang,Zhenghao Deng,Hui Xu
Siyuan Zhang
The molecular mechanisms underlying sex differences in acute kidney injury (AKI) remain incompletely understood. In a study recently published in Nature, Tonnus et al. reported that 17β-estradiol (E2) induces an anti-ferroptotic state in r...
Yuteng Liang,Weixin Chen,Qier Gao et al.
Yuteng Liang et al.
Type 2 diabetes (T2D) manifests as profound systemic metabolic dysregulation. Mounting evidence indicates T2D significantly impairs T cell immunity, compromising both protective immune responses and immune homeostasis. This dysfunction stem...