Squeezing Flux Out of Fat [0.03%]
挤出脂肪中的流量
Alba Gonzalez-Franquesa,Mary-Elizabeth Patti
Alba Gonzalez-Franquesa
Merging transcriptomics or metabolomics data remains insufficient for metabolic flux estimation. Ramirez et al. integrate a genome-scale metabolic model with extracellular flux data to predict and validate metabolic differences between whit...
Johan E Harris,Lisa A Baer,Kristin I Stanford
Johan E Harris
The intrauterine environment can modulate the course of development and confer an enduring effect on offspring health. The effects of maternal diet to impair offspring metabolic health are well established, but the effects of maternal exerc...
ATP Citrate Lyase: A New Player Linking Skeletal Muscle Metabolism and Epigenetics [0.03%]
丙二酸酶：一个连接骨骼肌代谢和表观遗传学的新因素
Haisen Li,Vittorio Sartorelli
Haisen Li
Intermediates generated in several metabolic processes are used to regulate transcription through covalent histone and DNA modifications. In Cell Reports, Das et al. show that acetyl-coenzyme A (acetyl-CoA) generated by ATP citrate lyase (A...
Kenji Ikeda,Pema Maretich,Shingo Kajimura
Kenji Ikeda
Two types of thermogenic fat cells, brown adipocytes and beige adipocytes, play a key role in the regulation of systemic energy homeostasis in mammals. Both brown fat and beige fat possess thermogenic properties in addition to common morpho...
Decio L Eizirik,Anne Op de Beeck
Decio L Eizirik
Enteroviruses are important environmental contributors to islet inflammation (insulitis) in type 1 diabetes mellitus (T1DM). A recent study characterized the proteomic alterations induced by Coxsackievirus type B (CVB) infection of human is...
Changting Xiao,Priska Stahel,Alicia L Carreiro et al.
Changting Xiao et al.
Dietary lipid absorption and lipoprotein secretion by the gut are important in maintaining whole-body energy homeostasis and have significant implications for health and disease. The processing of dietary lipids, including storage within an...
Ailine Stolz,Gilbert Schönfelder,Marlon R Schneider
Ailine Stolz
Although endocrine disruptors represent a serious concern to human health, the underlying molecular mechanisms leading to diseases such as cancer remain poorly understood. Recent work has uncovered the epidermal growth factor receptor (EGFR...
Julia Loeffler,Georg N Duda,F Andrea Sass et al.
Julia Loeffler et al.
Over the past years, basic findings in cancer research have revealed metabolic symbiosis between different cell types to cope with high energy demands under limited nutrient availability. Although this also applies to regenerating tissues w...
Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus [0.03%]
棕榈酸和油酸：2型糖尿病脂毒性的阴阳两面
Xavier Palomer,Javier Pizarro-Delgado,Emma Barroso et al.
Xavier Palomer et al.
Increased plasma non-esterified fatty acids (NEFAs) link obesity with insulin resistance and type 2 diabetes mellitus (T2DM). However, in contrast to the saturated FA (SFA) palmitic acid, the monounsaturated FA (MUFA) oleic acid elicits ben...
Jillian L Rourke,Queenie Hu,Robert A Screaton
Jillian L Rourke
If left unchecked, prediabetic hyperglycemia can progress to diabetes and often life-threatening attendant secondary complications. Central to the process of glucose homeostasis are pancreatic β cells, which sense elevations in plasma gluc...