FISH-ing Novel Dynamic Modes of Glucocorticoid-Induced Chromatin Reorganization [0.03%]
揭秘糖皮质激素诱导的染色质重构的新型动态模式
Felicity E Stubbs,Benjamin P Flynn,Becky L Conway-Campbell
Felicity E Stubbs
In a recent study, Jubb et al. used 3D DNA FISH to assess glucocorticoid-induced 'chromatin decompaction' at multiple loci. Determinants of the specificity, speed, and duration of this phenomenon further enhance our understanding of how the...
Allison W Xu
Allison W Xu
Bile acids facilitate dietary fat absorption upon release into the small intestine after a meal. A recent study by Liu and colleagues identifies a gut-brain axis wherein bile acids signal an energy-replete state to hypothalamic AgRP neurons...
Robert P Fisher
Robert P Fisher
Dependence on glycolysis under aerobic conditions, a frequent metabolic derangement in cancer cells, suggests a therapeutic opportunity. Now, through chemical genetics, CDK8, a kinase associated with the Mediator transcriptional coactivator...
Mohammed K Hankir,Florian Seyfried,Alexander D Miras et al.
Mohammed K Hankir et al.
Metabolic surgical procedures, such as Roux-en-Y gastric bypass (RYGB), uniquely reprogram feeding behavior and body weight in obese subjects. Clinical neuroimaging and animal studies are only now beginning to shed light on some of the unde...
Roberta Buono,Valter D Longo
Roberta Buono
Cancer cells are characterized by dysregulation in signal transduction and metabolic pathways leading to increased glucose uptake, altered mitochondrial function, and the evasion of antigrowth signals. Fasting and fasting-mimicking diets (F...
Glucagon-like Peptide-1 Receptor Agonists and Cardiovascular Events: Class Effects versus Individual Patterns [0.03%]
GLP-1受体激动剂与心血管事件：类效应还是个体差异？
Soo Lim,Kyoung Min Kim,Michael A Nauck
Soo Lim
Several new glucose-lowering medications have been approved, such as dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists (GLP-1RAs), and sodium glucose cotransporter-2 inhibitors. Among GLP-1RAs, lixisenatide, a sho...
Yan Tian,Boqiang Peng,Xianghui Fu
Yan Tian
The genetic etiology for obesity-related traits remains elusive. Recent studies link novel ADCY3 variants to obesity and diabetes, and identify an important role of ADCY3-mediated signaling at neuronal primary cilia in the predisposition of...
Livio Casarini,Daniele Santi,Manuela Simoni et al.
Livio Casarini et al.
It is common opinion that maximal activation of luteinizing hormone (LH)-dependent steroidogenic signal occurs at
Miguel López
Miguel López
Hypothalamic AMP-activated protein kinase (AMPK) is an important modulator of whole-body energy homeostasis, particularly within the ventromedial nucleus, where it regulates energy expenditure, glucose, and lipid metabolism. A recent paper ...
Abdul-Rizaq Hamoud,Lauren Weaver,David E Stec et al.
Abdul-Rizaq Hamoud et al.
Bilirubin is a component of the heme catabolic pathway that is essential for liver function and has been shown to reduce hepatic fat accumulation. High plasma bilirubin levels are reflective of liver disease due to an injurious effect on he...