Athan G Dial,Sean Y Ng,Alexander Manta et al.
Athan G Dial et al.
AMP-activated protein kinase (AMPK) is a primary regulator of cellular metabolism. Recent studies have revealed that AMPK also mediates the maintenance and plasticity of α-motoneurons, the neuromuscular junction, and skeletal muscle. Furth...
Björn Dahlbäck
Björn Dahlbäck
In Cell Reports, Christoffersen et al. [1] demonstrate that sphingosine 1-phosphate (S1P) bound to apolipoprotein M (apoM) regulates the activity and mass of brown adipose tissue (BAT). They found mice lacking apoM to have hyperactive BAT w...
Weight Loss and Adipose Tissue Browning in Humans: The Chicken or the Egg? [0.03%]
人类的体重减轻与脂肪褐变：孰因孰果？
Lucia Balazova,Christian Wolfrum,Miroslav Balaz
Lucia Balazova
Recruitment of thermogenic adipocytes within white fat depots represents a promising strategy to increase energy expenditure. Negative energy balance has been reported to promote adipose tissue browning in rodents. In a recent issue of Cell...
Teja Devarakonda,Fadi N Salloum
Teja Devarakonda
The hormone relaxin has long been recognized for its involvement in maternal adaptation during pregnancy. However, discoveries during the past two decades on the mechanism of action of relaxin, its family of receptors, and newly described r...
Ana D Mandić,Michael Blaut
Ana D Mandić
In a recent article in Cell Reports, Dalby and colleagues convincingly demonstrate that choosing an inadequate control diet in animal experiments that investigate the interaction of nutrition, gut microbiota, and obesity development may lea...
David Bargiela,Stephen P Burr,Patrick F Chinnery
David Bargiela
Alterations in mitochondrial metabolism influence cell differentiation and growth. This process is regulated by the activity of 2-oxoglutarate (2OG)-dependent dioxygenases (2OGDDs) - a diverse superfamily of oxygen-consuming enzymes - throu...
GR-regulating Serine/Threonine Kinases: New Physiologic and Pathologic Implications [0.03%]
泛素连接酶GRINA通过新的泛素化位点调节糖皮质激素受体：生理和病理意义
Tomoshige Kino
Tomoshige Kino
Glucocorticoid hormones, end products of the hypothalamic-pituitary-adrenal axis, virtually influence all human functions both in a basal homeostatic condition and under stress. The glucocorticoid receptor (GR), a nuclear hormone receptor s...
Erratum to 'Tyrosine Kinase Inhibitors and Diabetes: A Novel Treatment Paradigm?': [Trends in Endocrinology & Metabolism 26 (2015) 643-656] [0.03%]
《酪氨酸激酶抑制剂与糖尿病：一种新的治疗模式？》一文的勘误：[Trends in Endocrinology & Metabolism 26 (2015) 643-656]
Athanasios Fountas,Leonidas-Nikolaos Diamantopoulos,Agathocles Tsatsoulis
Athanasios Fountas
Erratum to 'Ltb4r1 inhibitor: A pivotal insulin sensitizer?': [Trends in Endocrinology and Metabolism, May 2015, Vol. 26, No. 5, 221-222] [0.03%]
《LTB4R1抑制剂：一个关键的胰岛素增敏剂？》一文勘误
Saeed Esmaili,Jacob George
Saeed Esmaili
Sergej M Ostojic
Sergej M Ostojic
Dysbiosis of the gut flora accompanies Parkinson disease (PD), yet no specific cause-effect link has been identified so far. The gut microbiota produce molecular hydrogen (H2), a ubiquitous molecule recently recognized as a biologically act...