The Endothelial-Metabolic Axis: A Novel Cardiometabolic Disease Target [0.03%]
内皮-代谢轴：心血管代谢性疾病的新型治疗靶点
Jason C Kovacic
Jason C Kovacic
Endothelial to mesenchymal transition (EndMT) involves cellular phenotypic switching from an endothelial to mesenchymal state. Interest in EndMT has been increasing with the appreciation that it has an important role in several cardiovascul...
Peter Mirtschink,Triantafyllos Chavakis
Peter Mirtschink
Notch signaling contributes to maintenance of adult tissue homeostasis and is also involved in disease. A recent study demonstrates that inhibition of Dll4-Notch signaling by anti-Dll4 improves pancreatic islet function and insulin producti...
Amar M Singh,Stephen Dalton
Amar M Singh
Human stem cell-based models of thermogenic adipocytes provide an opportunity for the establishment of new therapeutics, modeling of disease mechanisms, and understanding of development. Pluripotent stem cells, adipose-derived stem cells/pr...
Salma Kaochar,Nicholas Mitsiades
Salma Kaochar
Androgen receptor signaling is critical for prostate adenocarcinoma, even after androgen deprivation therapy. Persistence of intratumoral androgens has been found in castration-resistant prostate cancer and attributed to increased in situ s...
André Franz,Thorsten Hoppe
André Franz
Labbadia et al. showed that low-dose mitochondrial stress promotes protein homeostasis in the cytosol to endure proteotoxic conditions, particularly during aging. This hormetic mitochondrial stress response is heat shock factor 1 (HSF1)-dep...
Endocrine, Paracrine, and Autocrine Signaling Pathways That Regulate Ovulation [0.03%]
调控排卵的内分泌、旁分泌和自分泌信号通路
JoAnne S Richards,Mario Ascoli
JoAnne S Richards
The central role of luteinizing hormone (LH) and its receptor (LHCGR) in triggering ovulation has been recognized for decades. Because the LHCGR is present in the mural (outermost) granulosa cell layer of preovulatory follicles (POFs), the ...
High Glycemic Index Metabolic Damage - a Pivotal Role of GIP and GLP-1 [0.03%]
高血糖指数代谢损伤-GIP和GLP-1的关键作用
Andreas F H Pfeiffer,Farnaz Keyhani-Nejad
Andreas F H Pfeiffer
When glucose-fructose dimers are supplied as the slowly digestible, completely absorbable, low glycemic index (GI) sugar isomaltulose, the detrimental effects of high GI sucrose are avoided. This difference requires the presence of intact g...
Robin van Eenige,Mario van der Stelt,Patrick C N Rensen et al.
Robin van Eenige et al.
White adipose tissue (WAT) stores excess energy as triglycerides, and brown adipose tissue (BAT) is specialized in dissipating energy as heat. The endocannabinoid system (ECS) is involved in a broad range of physiological processes and is i...
Jiayi Li,Fan Bai,Biao Li et al.
Jiayi Li et al.
Mark W Hamrick,Meghan E McGee-Lawrence
Mark W Hamrick
Osteocytes are cells nested within the mineralized bone matrix that play a key role in maintaining bone mass. New findings in Cell Reports show that β-aminoisobutyric acid (l-BAIBA), a metabolite secreted from muscle, promotes osteocyte su...