Bhagirath Chaurasia,William L Holland,Scott A Summers
Bhagirath Chaurasia
Chaurasia and colleagues discuss the provocative new finding that some enzymes in the de novo sphingolipid synthesis pathway have dual roles as transcriptional regulators. ...
Biao Li,Jingjing Fan,Ning Chen
Biao Li
MiR-143 is an miRNA with the function of specifically inhibiting the insulin-AKT pathway via the downregulation of oxysterol-binding protein-related protein 8 (ORP8), thus resulting in the inhibition of AKT phosphorylation, insulin toleranc...
Mild Suppression of Hyperinsulinemia to Treat Obesity and Insulin Resistance [0.03%]
轻度抑制高胰岛素血症治疗肥胖和胰岛素抵抗
Melissa M Page,James D Johnson
Melissa M Page
Insulin plays roles in lipid uptake, lipolysis, and lipogenesis, in addition to controlling blood glucose levels. Excessive circulating insulin is associated with adipose tissue expansion and obesity, yet a causal role for hyperinsulinemia ...
Beyond LDL: What Role for PCSK9 in Triglyceride-Rich Lipoprotein Metabolism? [0.03%]
超越LDL：PCSK9在富含甘油三酯的脂蛋白代谢中扮演什么角色？
Wieneke Dijk,Cédric Le May,Bertrand Cariou
Wieneke Dijk
Elevated plasma triglyceride (TG) levels are an independent risk factor for cardiovascular disease (CVD). Proprotein convertase subtilisin-kexin 9 (PCSK9) - a protein therapeutically targeted to lower plasma cholesterol levels - might regul...
Prevention and Treatment of Type 2 Diabetes: A Pathophysiological-Based Approach [0.03%]
基于病理生理学的2型糖尿病防治方法
Dorit Samocha-Bonet,Sophie Debs,Jerry R Greenfield
Dorit Samocha-Bonet
Prediabetes affects approximately 40% of American adults. Randomized trials report that a proportion of individuals with prediabetes develop diabetes despite caloric restriction, physical activity, and/or when treated with metformin, the fi...
NDUFA4 (Renamed COXFA4) Is a Cytochrome-c Oxidase Subunit [0.03%]
线粒体复合物Ⅳ亚基新基因COXFA4 (原名NDUFA4)的克隆和表达分析
Robert D S Pitceathly,Jan-Willem Taanman
Robert D S Pitceathly
Groundbreaking work by Kadenbach and colleagues in the 1980s revealed the presence of 13 subunits in the mammalian mitochondrial cytochrome-c oxidase (COX; Complex IV). This observation stood the test of time until 2012 when it was demonstr...
Shih-Chi Su,Russel J Reiter,Hui-Yi Hsiao et al.
Shih-Chi Su et al.
Melatonin was discovered in the pineal gland and first came to be known as a biochemical synchronizer of circadian rhythm. The molecular mechanisms underlying the broad-spectrum actions of melatonin are not restricted to its interaction wit...
Carmen Berasain,Matías A Ávila
Carmen Berasain
The pleiotropic liver kinase B1 (LKB1) controls metabolism, cell polarity, and proliferation in an apparently cell- and context-specific manner. A recent study in Cell Reports has demonstrated that LKB1 is essential to maintain the characte...
Yahya Sohrabi,Rinesh Godfrey,Hannes M Findeisen
Yahya Sohrabi
Exposing innate immune cells to an initial insult induces a long-term proinflammatory response due to metabolic and epigenetic alterations which encompass an emerging new concept called trained immunity. Recent studies provide novel insight...
Nina Weisshaar,Alaa Madi,Guoliang Cui
Nina Weisshaar
T cells rapidly engage glycolysis upon activation. The signaling pathways through which T cell receptor (TCR) activation initiates glycolysis have been a mystery. A long-awaited answer has been provided by Menk et al., who show that pyruvat...