Ali Aminian
Ali Aminian
Roux-en-Y gastric bypass and sleeve gastrectomy (SG) are fairly similar in terms of their long-term effects on excess body weight, cardiometabolic risk factors, and quality of life. However, SG appears to be a safer procedure with distinct ...
Environmental Signals Influencing Myeloid Cell Metabolism and Function in Diabetes [0.03%]
影响糖尿病中髓系细胞代谢和功能的环境信号分子
Jacqueline M Ratter,Cees J Tack,Mihai G Netea et al.
Jacqueline M Ratter et al.
The environment induces metabolic reprogramming of immune cells via specific signaling pathways. Recent studies have revealed that changes in cell metabolism affect key immune cell functions including cytokine production and migration. In d...
Molecular Mechanisms Governing Embryonic Differentiation of Pituitary Somatotropes [0.03%]
调控垂体生长激素细胞胚胎分化的分子机制
Buffy S Ellsworth,Caitlin E Stallings
Buffy S Ellsworth
Pituitary somatotropes secrete growth hormone (GH), which is essential for normal growth and metabolism. Somatotrope defects result in GH deficiency (GHD), leading to short stature in childhood and increased cardiovascular morbidity and mor...
Suowen Xu,Jaroslav Pelisek,Zheng Gen Jin
Suowen Xu
Atherosclerosis is a chronic inflammatory and lipid-depository disease that eventually leads to acute cardiovascular events. Emerging evidence supports that epigenetic processes such as DNA methylation, histone modification, and noncoding R...
GABAergic Signaling Mediates Central Cardiovascular Angiotensin II Type 2 Receptor Effects [0.03%]
中枢血管加压素II型受体的作用介导于γ-氨基丁酸能信号传导过程中
Laura Légat,Ilse Smolders,Alain G Dupont
Laura Légat
Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism [0.03%]
斑马鱼信号通路成为细胞和全身代谢中的关键新兴路径
Amin Ardestani,Blaz Lupse,Kathrin Maedler
Amin Ardestani
The evolutionarily conserved Hippo pathway is a key regulator of organ size and tissue homeostasis. Its dysregulation is linked to multiple pathological disorders. In addition to regulating development and growth, recent studies show that H...
Advances in the Molecular Pathophysiology, Genetics, and Treatment of Primary Ovarian Insufficiency [0.03%]
原发性卵巢功能不全的分子病理生理学、遗传学和治疗进展
Ilpo Huhtaniemi,Outi Hovatta,Antonio La Marca et al.
Ilpo Huhtaniemi et al.
Primary ovarian insufficiency (POI) affects ∼1% of women before 40 years of age. The recent leap in genetic knowledge obtained by next generation sequencing (NGS) together with animal models has further elucidated its molecular pathogenesi...
San-Pin Wu,Rong Li,Francesco J DeMayo
San-Pin Wu
Progesterone acts through the progesterone receptor to direct physiological adaption of the uterus in preparation and completion of pregnancy. Genome-wide transcriptome and cistrome analyses have uncovered new members and novel modifiers of...
Anders M Näär
Anders M Näär
The miR-33 microRNAs (miRNAs) are crucial regulators of cholesterol/lipids, and may represent therapeutic targets for the treatment of atherosclerosis. A recent report by Price et al. showed that miR-33 knockout (KO) mice exhibit obesity, i...
Christopher J Halbrook,Zeribe C Nwosu,Costas A Lyssiotis
Christopher J Halbrook
Metabolic processes within cells are dynamically interconnected. If mitochondria become defective, cells must rewire their metabolism to survive. Here we highlight recent work by Gaude et al. that used a tunable model of mitochondrial dysfu...