Pink Adipocytes [0.03%]
粉红脂肪细胞
Saverio Cinti
Saverio Cinti
Adipocytes are lipid-rich parenchymal cells contained in a very plastic organ, whose composition can undergo striking physiologic changes. In standard conditions the organ contains white and brown adipocytes which play opposite roles: lipid...
Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism [0.03%]
深入表观基因组：影响细胞代谢的染色质存储器
Cunqi Ye,Benjamin P Tu
Cunqi Ye
Epigenetic modifications on chromatin are most commonly thought to be involved in the transcriptional regulation of gene expression. Due to their dependency on small-molecule metabolites, these modifications can relay information about cell...
Extragonadal Effects of Follicle-Stimulating Hormone on Osteoporosis and Cardiovascular Disease in Women during Menopausal Transition [0.03%]
促性腺激素对女性围绝经期骨质疏松和心血管疾病的影响
Dongxing Zhu,Xiaosa Li,Vicky E Macrae et al.
Dongxing Zhu et al.
The risk of osteoporosis and cardiovascular disease increases significantly in postmenopausal women. Until recently, the underlying mechanisms have been primarily attributed to estrogen decline following menopause. However, follicle-stimula...
Brett McKinnon,Michael Mueller,Grant Montgomery
Brett McKinnon
Endometriosis is the growth of endometrial tissue outside the uterus and is characterized by progesterone resistance and changes in global and progesterone target gene expression. However, the mechanism behind this and whether it is innate,...
Geoffroy de Faudeur,Bas Brouwers,Frans Schuit et al.
Geoffroy de Faudeur et al.
The minigene encoding human growth hormone (hGH) has been incorporated into over 300 transgenic mouse lines to improve transgene expression. However, unexpected and functional hGH expression can drastically alter physiology. We list here th...
Yu-Chan Chang,Yi-Chieh Yang,Chia-Ping Tien et al.
Yu-Chan Chang et al.
The aldolase family members involved in metabolism and glycolysis are present in three isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human tissues, and aberrant expression has been observed in several human di...
Scott J Bultman
Scott J Bultman
In a recent Cell Reports article, Li et al. report that obesity is associated with altered fatty acid metabolism and DNA methylation in the colonic epithelium, which precede a tumor-prone gene-expression profile. Interestingly, obesity-asso...
Uniting GDF15 and GFRAL: Therapeutic Opportunities in Obesity and Beyond [0.03%]
GDF15和GFRAL的结合：肥胖及其他疾病的治疗机遇
Shannon E Mullican,Shamina M Rangwala
Shannon E Mullican
Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. The potent...
Hypothalamic Control of Systemic Glucose Homeostasis: The Pancreas Connection [0.03%]
下丘脑对全身葡萄糖稳态的调控：胰腺连接
Macarena Pozo,Marc Claret
Macarena Pozo
Maintenance of glucose homeostasis is mandatory for organismal survival. It is accomplished by complex and coordinated interplay between glucose detection mechanisms and multiple effector systems. The brain, in particular homeostatic region...
Kristina I Rother,Ellen M Conway,Allison C Sylvetsky
Kristina I Rother
Non-nutritive sweeteners (NNSs) elicit a multitude of endocrine effects in vitro, in animal models, and in humans. The best-characterized consequences of NNS exposure are metabolic changes, which may be mediated by activation of sweet taste...