Nutritional Modulation of Innate Immunity: The Fat-Bile-Gut Connection [0.03%]
营养调节先天免疫：脂肪-胆汁-肠道的相互作用
Raphael Chevre,Carlos Silvestre-Roig,Oliver Soehnlein
Raphael Chevre
Altered nutritional behavior in Western societies has unleashed numerous metabolic disorders, intimately linked to profound disruptions of the immune system. Here we summarize how nutrition modulates innate immunity. We outline recent findi...
New Perspectives on the Pathogenesis of PCOS: Neuroendocrine Origins [0.03%]
从神经内分泌起源角度审视多囊卵巢综合征的新观点
Kirsty A Walters,Robert B Gilchrist,William L Ledger et al.
Kirsty A Walters et al.
Polycystic ovary syndrome (PCOS) is the most common endocrine condition in reproductive-aged women. It is characterized by reproductive, endocrine, metabolic, and psychological features. The cause of PCOS is unknown, thus there is no cure a...
Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential [0.03%]
盐诱导蛋白激酶：生理、环磷腺苷调节和潜在治疗作用
Marc N Wein,Marc Foretz,David E Fisher et al.
Marc N Wein et al.
Salt-inducible kinases (SIKs) represent a subfamily of AMP-activated protein kinase (AMPK) family kinases. Initially named because SIK1 (the founding member of this kinase family) expression is regulated by dietary salt intake in the adrena...
Metabolic Stress, Autophagy, and Cardiovascular Aging: from Pathophysiology to Therapeutics [0.03%]
代谢压力、自噬和心血管衰老：从病理生理学到治疗学
Jun Ren,James R Sowers,Yingmei Zhang
Jun Ren
Recent advances in health care have improved the management of cardiometabolic disorders, and prolonged lifespan. However, the ever-rising prevalence of metabolic stress related to obesity (insulin resistance, diabetes, hypertension, and dy...
Jingjing Cai,Xiao-Jing Zhang,Hongliang Li
Jingjing Cai
Non-alcoholic fatty liver disease (NAFLD) has become the most epidemic liver disease worldwide owing to rapid changes in lifestyle over the past few decades. This chronic condition intertwines with low-grade inflammation and metabolic diseq...
Transgenerational Epigenetic Mechanisms in Adipose Tissue Development [0.03%]
adipogenesis中的跨世代表观遗传机制
Simon Lecoutre,Paul Petrus,Mikael Rydén et al.
Simon Lecoutre et al.
An adverse nutritional environment during the perinatal period increases the risk of adult-onset metabolic diseases, such as obesity, which may persist across generations. Adipose tissue (AT) from offspring of malnourished dams has been sho...
Amin Ardestani,Kathrin Maedler
Amin Ardestani
Mechanistic target of rapamycin complex (mTORC)1 is the major regulator of metabolism at the cellular and organismal level. mTORC1-mediated regulatory feedback loops enable adaptation to nutrient and growth factor availability and metabolic...
Xue Jiao,Hanni Ke,Yingying Qin et al.
Xue Jiao et al.
Premature ovarian insufficiency (POI) is highly heterogeneous in genetic etiology. Yet identifying causative genes has been challenging with candidate gene approaches. Recent approaches using next generation sequencing (NGS), especially who...
Rajashree Mishra,Kenyaita M Hodge,Diana L Cousminer et al.
Rajashree Mishra et al.
Latent autoimmune diabetes in adults (LADA) is characterized by the presence of islet autoantibodies and initial insulin independence, which can lead to misdiagnosis of type 2 diabetes (T2D). As such, understanding the genetic etiology of L...
Almudena Veiga-Lopez,Yong Pu,Jeremy Gingrich et al.
Almudena Veiga-Lopez et al.
Endocrine disrupting chemicals (EDCs) are compounds that are part of everyday consumer products and industrial manufacturing processes. EDCs can interfere with the endocrine system, including the adipose tissue. Accumulating evidence from e...