Christine A Mills,Alec G Trub,Matthew D Hirschey
Christine A Mills
Fatty acid synthesis (FAS) in mitochondria produces a key metabolite called lipoic acid. However, a new study by Van Vranken et al.[1] (Mol. Cell 2018;71:567-580) shows that mitochondrial FAS regulates the assembly of oxidative phosphorylat...
Kei Sakamoto,Laurent Bultot,Olga Göransson
Kei Sakamoto
The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible ...
Firing Up Glycolysis: BCG Vaccination Effects on Type 1 Diabetes Mellitus [0.03%]
糖酵解激活：卡介苗疫苗对1型糖尿病的影响
Rinke Stienstra,Mihai G Netea
Rinke Stienstra
In addition to the impact of Bacillus Calmette-Guerin (BCG) vaccination on antimicrobial host defence, a novel study reveals beneficial effects on glycaemic control in patients with long-standing type 1 diabetes mellitus (T1DM). These effec...
Jianhua Xiong
Jianhua Xiong
Metabolism has recently been in the spotlight because of technical advances in metabolite measurement; however, it is not a new topic in the Nobel Prize's history. Emerging evidence suggests that metabolism is more complex than was previous...
Francis de Zegher,Abel López-Bermejo,Lourdes Ibáñez
Francis de Zegher
Polycystic ovary syndrome (PCOS) development commonly starts with a mismatch between pre- and postnatal weight gain, leading to hepatovisceral fat excess. To escape from such central obesity, girls may accelerate their growth and/or maturat...
Emma C Johns,Fiona C Denison,Jane E Norman et al.
Emma C Johns et al.
Gestational diabetes mellitus (GDM) is the most common metabolic disturbance during pregnancy. The prevalence is rising and correlates with the increase in maternal obesity over recent decades. The etiology of GDM is complex, with genetic a...
Inositol in Polycystic Ovary Syndrome: Restoring Fertility through a Pathophysiology-Based Approach [0.03%]
基于病理生理学的多囊卵巢综合征治疗以肌醇恢复生育能力
Antonio Simone Laganà,Simone Garzon,Jvan Casarin et al.
Antonio Simone Laganà et al.
Myo-inositol (MI) and D-chiro-inositol (DCI) are insulin second messengers, and MI is involved in follicular gonadotropin pathways which orchestrate ovulation. The tissue-specific MI/DCI ratio is modulated by insulin through aromatase and i...
Endothelial Cells: New Players in Obesity and Related Metabolic Disorders [0.03%]
血管内皮细胞在肥胖及相关代谢紊乱中的新作用
Mariona Graupera,Marc Claret
Mariona Graupera
Metabolic disorders such as obesity are accompanied by endothelial cell (EC) dysfunction and decreased vascular density. The current paradigm posits that metabolic alterations associated with obesity secondarily lead to EC dysfunction. Howe...
Z Hochberg
Z Hochberg
An evolutionary approach to obesity involves a genomic/anthropological dimension. For 1.8 Myr the lifestyle of hunter-gatherers (HGs) comprised intense physical activity and a high-protein/low-carbohydrate diet. Genomes of HGs were adapted ...
Yuichi Takashi,Seiji Fukumoto
Yuichi Takashi
Fibroblast growth factor (FGF) 23 is a bone-derived phosphotropic hormone that regulates phosphate and vitamin D metabolism. FGF23 mainly affects kidney function via the FGF receptor (FGFR)/α-Klotho complex. The physiological roles of FGF2...