Sodium Glucose Co-transporter Inhibitors in Patients with Acromegaly and Diabetes [0.03%]
糖尿病伴肢端肥大症患者的钠葡萄糖共转运体抑制剂治疗
Zaina Adnan
Zaina Adnan
Acromegaly per se predisposes to diabetes. Somatostatin analogs (SSAs) have an overall neutral effect on glycemic control. However, a marked increase in hyperglycemia was observed recently since the introduction of pasireotide long-acting r...
Handan Melike Dönertaş,Matías Fuentealba,Linda Partridge et al.
Handan Melike Dönertaş et al.
Increasing human life expectancy has posed increasing challenges for healthcare systems. As people age, they become more susceptible to chronic diseases, with an increasing burden of multimorbidity, and the associated polypharmacy. Accumula...
Ilja L Kruglikov,Zhuzhen Zhang,Philipp E Scherer
Ilja L Kruglikov
Hair follicles (HFs) strongly interact with adipocytes within the dermal white adipose tissue (dWAT), suggesting a strong physiological dependence on the content of immature and mature adipocytes in this layer. This content is regulated by ...
Sphingolipids in the Pathogenesis of Parkinson's Disease and Parkinsonism [0.03%]
鞘脂在帕金森病和帕金森症发病机制中的作用
Guang Lin,Liping Wang,Paul C Marcogliese et al.
Guang Lin et al.
The pathogenic mechanisms underlying Parkinson's disease (PD)/parkinsonism affect mitochondrial and endolysosomal trafficking. The retromer is required to retrieve some proteins from endosomes to the Golgi and plasma membrane. Here, we disc...
Jiali Yang,Lingrong Wen,Yueming Jiang et al.
Jiali Yang et al.
Estrogen receptors (ERs) are transcription factors highly involved in physiological development and metabolism in the human body. They also play important roles in the treatment of cancer and metabolic diseases. Chemicals that interact with...
Jonathan H Pérez,Elisabetta Tolla,Ian C Dunn et al.
Jonathan H Pérez et al.
Ubiquitous in non-mammalian vertebrates, extra-retinal photoreceptors (ERPs) have been linked to an array of physiological, metabolic, behavioral, and morphological changes. However, the mechanisms and functional roles of ERPs remain one of...
Varykina G Thackray
Varykina G Thackray
Recent studies have shown that sex and sex steroids influence the composition of the gut microbiome. These studies also indicate that steroid regulation of the gut microbiome may play a role in pathological situations of hormonal excess, su...
Juan Domínguez-Bendala,Mirza Muhammad Fahd Qadir,Ricardo Luis Pastori
Juan Domínguez-Bendala
Adult pancreatic regeneration is one of the most contentious topics in modern biology. The long-held view that the islets of Langerhans can be replenished throughout adult life through the reactivation of ductal progenitor cells has been re...
High-Density Lipoprotein Components and Functionality in Cancer: State-of-the-Art [0.03%]
癌症中的高密度脂蛋白组成和功能：最新研究进展
Shiva Ganjali,Biagio Ricciuti,Matteo Pirro et al.
Shiva Ganjali et al.
Cancer is the second leading cause of death in western countries, and thus represents a major global public health issue. Whilst it is well-recognized that diet, obesity, and smoking are risk factors for cancer, the role of low levels of hi...
Eylem Kulkoyluoglu-Cotul,Alexandra Arca,Zeynep Madak-Erdogan
Eylem Kulkoyluoglu-Cotul
Estrogens and estrogen receptors (ERs) regulate metabolism in both normal physiology and in disease. The metabolic characteristics of intrinsic breast cancer subtypes change based on their ER expression. Crosstalk between estrogen signaling...