Leah D&#x;Silva,Chloe Cheng,Joeva J Barrow
Leah D&#x;Silva
Since the discovery that individuals with active brown adipose tissue (BAT) have lower prevalence of cardiometabolic diseases, it has been hypothesized that this depot can be targeted to improve human metabolic health. A major limitation wi...
Alexandra E Schneider,Colin C Conine
Alexandra E Schneider
Once controversial, paternal non-genetic inheritance is becoming widely accepted. In a recent study, Yin et al. expand this burgeoning field by demonstrating that the benefits of paternal exercise are passed to progeny via modulating sperm ...
Amandine Girousse,Virginie Bourlier,Coralie Sengenès
Amandine Girousse
Intramuscular adipose tissue (IMAT) is associated with impaired muscle regeneration, but whether it directly hinders recovery remains unclear. Norris and colleagues show that preventing IMAT formation after injury promotes new myofiber form...
Single-cell imaging of liver metabolic dynamics using fluorescent biosensors [0.03%]
用于肝脏代谢动态单细胞成像的荧光生物传感器
Israel Pérez-Chávez,Eduardo H Gilglioni,Daria Ezeriņa et al.
Israel Pérez-Chávez et al.
Traditional metabolic studies rely on bulk tissue analyses, masking the cellular heterogeneity that underlies disease progression. Genetically encoded fluorescent biosensors now enable real-time, single-cell imaging of dynamic metabolic pro...
Beatriz Rodriguez-Cortes,Ricardo Gomez-Martínez,Rachel Spenle et al.
Beatriz Rodriguez-Cortes et al.
Constant monitoring and fine-tuning of internal body status to maintain energy homeostasis despite changing physiological needs and environmental conditions are essential brain functions. Hypothalamic tanycytes - specialized ependymoglial c...
MASLD in childhood as a multisystem health challenge beyond the liver [0.03%]
儿童MASLD不仅仅是肝脏疾病：一种多系统健康挑战
Marica Esposito,Ida Rimauro,Vittoria Frattolillo et al.
Marica Esposito et al.
The rising prevalence of childhood obesity and type 2 diabetes has made metabolic dysfunction-associated steatotic liver disease (MASLD) an urgent pediatric health concern. Beyond its well-known hepatic and cardiometabolic burden, emerging ...
Tobias Carling
Tobias Carling
Adrenal tumors driving hormone excess, like primary aldosteronism, Cushing syndrome, and pheochromocytoma, claim thousands of lives yearly; yet, adrenalectomy remains underused despite its lifesaving potential. Ideal surgical rates in the U...
Daan A Jiskoot,Jeroen L A Pennings,Willie J G M Peijnenburg et al.
Daan A Jiskoot et al.
Endocrine-disrupting chemicals (EDCs) pose health risks; yet, conventional in vitro and in vivo testing remains slow, costly, and animal-intensive. Enhanced use of in silico approaches can contribute to earlier and increased detection of po...
Lu Zhang,Jian Zhang,Sijun Yang
Lu Zhang
Conventional obesity interventions create 'health information silos', isolating scientific knowledge from lived experience and systemic drivers. Artistic interventions can uniquely dismantle these silos by translating complex data into visc...
Ye Cao,Josephine M Kanta,Christopher A Bishop et al.
Ye Cao et al.
Dietary medium-chain triacylglycerols (MCTs; C8:0-C12:0) are absorbed and utilized differently compared with long-chain fats. They directly enter the portal vein as free medium-chain fatty acids, most of which are converted to ketone bodies...