Antipsychotics Promote Metabolic Disorders Disrupting Cellular Lipid Metabolism and Trafficking [0.03%]
抗精神病药物通过干扰细胞脂质代谢和转运促进代谢紊乱
Chiara Vantaggiato,Elena Panzeri,Andrea Citterio et al.
Chiara Vantaggiato et al.
Antipsychotics frequently cause obesity and related metabolic disorders that current psychopharmacological/endocrinological theories do not explain consistently. An integrative/alternative theory implies metabolic alterations happening at t...
Spatial Technologies in Obesity Research: Current Applications and Future Promise [0.03%]
肥胖研究中的空间技术：目前应用与未来前景
Peng Jia,Hong Xue,Li Yin et al.
Peng Jia et al.
Geographic Information Systems (GIS), Global Positioning Systems (GPS), and remote sensing (RS) are revolutionizing obesity-related research. The primary applications of GIS have included visualizing obesity outcomes and risk factors, const...
Zaher Merhi,Eleni A Kandaraki,Evanthia Diamanti-Kandarakis
Zaher Merhi
Human, animal, and in vitro studies provide evidence that advanced glycation end-products (AGEs) may contribute to the pathogenesis of polycystic ovary syndrome (PCOS) and its metabolic and reproductive consequences. AGEs are able to induce...
Andrew P Koutnik,Dominic P D&#x;Agostino,Brendan Egan
Andrew P Koutnik
The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) are the subject of renewed interest given recently established pleiotropic effects regulating inflammation, oxidative stress, and gene expression. Anticatabolic effects of ...
Metabolic Disease Epidemics: Emerging Challenges in Regenerative Medicine [0.03%]
代谢性疾病流行：再生医学面临的新兴挑战
Raquel Costa-Almeida,Rui L Reis,Manuela E Gomes
Raquel Costa-Almeida
The interplay between cell/tissue damage caused by metabolic dysfunction and regenerative potential remains elusive. The tissue engineering and regenerative medicine (TERM) field is now facing a worldwide epidemic of obesity. This Forum art...
Isin Cakir,Eduardo A Nillni
Isin Cakir
Overweight and obesity pose significant health problems globally, and are causatively linked to metabolic dysregulation. The hypothalamus integrates neural, nutritional, and hormonal cues to regulate homeostasis, including circadian rhythm,...
David E Place,Thirumala-Devi Kanneganti
David E Place
Understanding the molecular mechanisms by which diet and exercise regulate disease has the potential to help identify new treatments. In their recent study, Chakraborty et al. (Cell Reports 2018;25:677-689) discovered that supplementation w...
Yi Fang,Shuang Tang,Xiaoling Li
Yi Fang
Sirtuins are highly conserved NAD+-dependent enzymes that are capable of removing a wide range of lipid lysine acyl-groups from protein substrates in a NAD+-dependent manner. These NAD+-dependent activities enable sirtuins to monitor cellul...
BCG Therapy for Type 1 Diabetes: Restoration of Balanced Immunity and Metabolism [0.03%]
用于治疗1型糖尿病的卡介苗疗法：恢复平衡的免疫和代谢功能
Willem M Kühtreiber,Denise L Faustman
Willem M Kühtreiber
The bacillus Calmette-Guerin (BCG) vaccine is a microorganism developed as a vaccine for tuberculosis 100 years ago and used as therapy for bladder cancer 40 years ago. More recently, BCG has shown therapeutic promise for type 1 diabetes (T...
Timing Matters: Circadian Effects on Energy Homeostasis and Alzheimer's Disease [0.03%]
时间的影响：生物钟对能量平衡和阿尔茨海默病的作用
Aline Loehfelm,Alisa Boucsein,Dominik Pretz et al.
Aline Loehfelm et al.
Metabolic syndrome and Alzheimer's disease (AD) are two major health issues in modern society causing an extraordinary financial burden for the global healthcare systems. A tight link between the pathologies of obesity and type 2 diabetes (...