Reactive Oxygen Comes of Age: Mechanism-Based Therapy of Diabetic End-Organ Damage [0.03%]
活性氧成熟了：糖尿病靶器官损伤机制为基础的治疗
Mahmoud H Elbatreek,Mayra P Pachado,Antonio Cuadrado et al.
Mahmoud H Elbatreek et al.
Reactive oxygen species (ROS) have been mainly viewed as unwanted by-products of cellular metabolism, oxidative stress, a sign of a cellular redox imbalance, and potential disease mechanisms, such as in diabetes mellitus (DM). Antioxidant t...
David Balgoma,Curt Pettersson,Mikael Hedeland
David Balgoma
Recent studies have reported the upregulation of a subgroup of triacylglycerides as markers of different diseases with dysregulated lipogenesis, which means that these markers are not selective. This observation has a deep impact on their u...
Combined Antioxidant and Glucocorticoid Therapy for Safer Treatment of Preterm Birth [0.03%]
抗氧化剂与糖皮质激素联合治疗安全地预防早产
Tessa A C Garrud,Dino A Giussani
Tessa A C Garrud
Ante- and postnatal glucocorticoid therapy reduces morbidity and mortality in the preterm infant, and it is therefore one of the best examples of the successful translation of basic experimental science into human clinical practice. However...
Eunüs S Ali,Nikolai Petrovsky
Eunüs S Ali
Hepatic steatosis, the first step in nonalcoholic fatty liver disease (NAFLD), can arise from various pathophysiological conditions. While lipid metabolism in the liver is normally balanced such that there is no excessive lipid accumulation...
Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential: (Trends Endocrinol. Metab. 29, 723-735, 2018) [0.03%]
盐诱导蛋白激酶：生理作用、环磷腺苷调节机制及其潜在治疗价值：《内分泌学及代谢研究趋势》第29卷，第723-735页，2018年
Marc N Wein,Marc Foretz,David E Fisher et al.
Marc N Wein et al.
Jun Yoshino
Jun Yoshino
NAD+ has a pivotal role in regulating many biological processes. A recent study (Palzer et al., Cell Rep. 2018, 25;1359-1370) demonstrated that alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) is a key regulator of NAD+ ...
Eder Zavala,Kyle C A Wedgwood,Margaritis Voliotis et al.
Eder Zavala et al.
Hormone rhythms are ubiquitous and essential to sustain normal physiological functions. Combined mathematical modelling and experimental approaches have shown that these rhythms result from regulatory processes occurring at multiple levels ...
Dengbao Yang,Yihong Wan
Dengbao Yang
Abnormal nicotinamide adenine dinucleotide (NAD+) metabolism causes a wide spectrum of diseases. A recent study (Cell Rep. 2019;26:969-983) shows that postpartum NAD+ homeostasis is depressed. By restoring NAD+ homeostasis, maternal nicotin...
'Et Tu, Leptin?' [0.03%]
“连你也在乎瘦素？”
Diego Perez-Tilve
Diego Perez-Tilve
Leptin promotes adequate caloric intake and glycemia in healthy lean individuals, harnessing the benefits of the ideal therapy against metabolic syndrome. Yet, new evidence demonstrates an unexpected causal role for leptin in obesity-associ...
Veiled Potential of Secretagogin in Diabetes: Correlation or Coincidence? [0.03%]
糖尿病中隐蔽的分泌素潜力：相关还是巧合？
Anand Kumar Sharma,Radhika Khandelwal,Yogendra Sharma
Anand Kumar Sharma
Secretagogin (SCGN) is a calcium sensor protein enriched in neuroendocrine cells in general and pancreatic β-cells in particular. SCGN regulates insulin secretion through several Ca2+-dependent interactions. Recent studies implicate SCGN i...