Margherita T Cantorna,Connie J Rogers,Juhi Arora
Margherita T Cantorna
Inflammatory bowel disease (IBD) is a chronic disorder characterized by inflammation of the gastrointestinal tract and an immune-mediated attack against the commensal microbiota. Vitamin D is an essential vitamin that not only promotes calc...
Host-Microbe Interplay in the Cardiometabolic Benefits of Dietary Polyphenols [0.03%]
膳食多酚的 cardiometabolic益处中的宿主微生物相互作用
F F Anhê,B S Y Choi,J R B Dyck et al.
F F Anhê et al.
Polyphenols are nonessential phytonutrients abundantly found in fruits and vegetables. A wealth of data from preclinical models and clinical trials consistently supports cardiometabolic benefits associated with dietary polyphenols in murine...
Adipocyte Metabolism and Insulin Signaling Perturbations: Insights from Genetics [0.03%]
遗传学视角下的脂肪细胞代谢和胰岛素信号紊乱
Max Friesen,Chad A Cowan
Max Friesen
Insulin resistance (IR) is a rapidly growing pandemic. It poses an enormous health burden given its comorbidity with obesity, type 2 diabetes (T2D), and other metabolic and cardiovascular diseases (CVDs). Adipose tissue has been established...
Yi Rao
Yi Rao
It is not often that three misconceptions are associated with one molecule for more than a century. This is the case with adrenaline. The aim here is to clarify that adrenaline was the first hormone, with the discovery of its activity and c...
Kyra E de Goede,Karl J Harber,Jan Van den Bossche
Kyra E de Goede
Over the past decade, cancer metabolism research taught us that metabolites are much more than intermediate or end products of metabolism. As such, the name 'oncometabolite' emerged. Immunometabolism research has developed tremendously over...
Jan Martel,David M Ojcius,Yun-Fei Ko et al.
Jan Martel et al.
Caloric restriction, intermittent fasting, and exercise activate defensive cellular responses such as autophagy, DNA repair, and the induction of antioxidant enzymes. These processes improve health and longevity by protecting cells and orga...
Drew Duglan,Katja A Lamia
Drew Duglan
Research over the past century indicates that the daily timing of physical activity impacts on both immediate performance and long-term training efficacy. Recently, several molecular connections between circadian clocks and exercise physiol...
Elyssa Bernfeld,David A Foster
Elyssa Bernfeld
Cancer cells consume glutamine, a nonessential amino acid (NEAA), at exceedingly high rates to fulfill their energetic and biosynthetic requirements for proliferation. Glutamine plays distinct roles from essential amino acids in cell cycle ...
Novel Insights into Sensorimotor and Cardiovascular Autonomic Neuropathy from Recent-Onset Diabetes and Population-Based Cohorts [0.03%]
来自新发糖尿病和基于人群队列的运动感觉神经病变和心血管自主神经病变的新见解
Christian Herder,Michael Roden,Dan Ziegler
Christian Herder
The most prevalent chronic complications of diabetes are diabetic neuropathies, among which distal sensorimotor polyneuropathy (DSPN) and cardiovascular autonomic neuropathy (CAN) are the best studied. Their major clinical sequelae such as ...
Jorge Mendoza
Jorge Mendoza
Eating behavior is regulated by metabolic and hedonic brain networks, which interact with each other to balance the physiological regulation of hunger and satiety. The daily balance of this regulation is controlled by the central circadian ...