Anoop Singh Chauhan,Li Zhuang,Boyi Gan
Anoop Singh Chauhan
RIG-I-like receptor (RLR)-mediated interferon production is critical for antiviral responses. A recent study (Zhang et al., Cell, 2019) uncovered a reciprocal inhibition between RLR signaling and glycolysis: lactate produced by glycolysis i...
Sabrina Chiloiro,Ettore Domenico Capoluongo,Tommaso Tartaglione et al.
Sabrina Chiloiro et al.
Hypophysitis is a rare and potentially life-threatening disease, characterized by an elevated risk of complications, such as occurrence of acute central hypoadrenalism, persistent hypopituitarism, or extension of the inflammatory process to...
Julie Massart,Juleen R Zierath
Julie Massart
Diacylglycerol kinases (DGKs) catalyze a reaction that converts diacylglycerol (DAG) to phosphatidic acid (PA). DAG and PA act as intermediates of de novo lipid synthesis, cellular membrane constituents, and signaling molecules. DGK isoform...
Interactive and Multifactorial Mechanisms of Calcific Vascular and Valvular Disease [0.03%]
血管和瓣膜钙化的交互及多因素机制
Linda L Demer,Yin Tintut
Linda L Demer
Calcific vascular and valvular disease (CVVD) is widespread and has major health consequences. Although coronary artery calcification has long been associated with hyperlipidemia and increased mortality, recent evidence suggests that its pr...
Epigenetics and Exercise [0.03%]
表观遗传学和运动
Sean L McGee,Mark Hargreaves
Sean L McGee
Epigenetics can be defined as 'the structural adaptation of chromosomal regions so as to register, signal, or perpetuate altered activity states.' Increased transcription of key regulatory, metabolic, and myogenic genes is an early response...
Adult Cardiomyocyte Cell Cycle Detour: Off-ramp to Quiescent Destinations [0.03%]
成人心肌细胞细胞周期旁路：通往静止状态的分流道路
Kathleen M Broughton,Mark A Sussman
Kathleen M Broughton
Ability to promote completion of mitotic cycling of adult mammalian cardiomyocytes remains an intractable and vexing challenge, despite being one of the most sought after 'holy grails' of cardiovascular research. While some of the struggle ...
Eleonore Fröhlich,Richard Wahl
Eleonore Fröhlich
The microbiota has been identified as an important factor in health and in a variety of diseases. An altered microbiota composition increases the prevalence of Hashimoto's thyroiditis (HT) and Graves' disease (GD). Microbes influence thyroi...
Reactive Carbonyl Species: Diabetic Complication in the Heart and Lungs [0.03%]
活性醛类物质：糖尿病心脏和肺部并发症的发病机制
Cheng-Ju Tian,Zhong Zhen
Cheng-Ju Tian
Abnormal chemical reactions in hyperglycemia alter normal metabolic processes in diabetes, which is a key process in the production of reactive carbonyls species (RCS). Increasing the concentration of RCS may result in carbonyl/oxidative st...
Jo E Lewis,Francis J P Ebling,Ricardo J Samms et al.
Jo E Lewis et al.
Fibroblast growth factor 21 (FGF21) is a protein highly synthesized in the liver that exerts paracrine and endocrine control of many aspects of energy homeostasis in multiple tissues. In preclinical models of obesity and type 2 diabetes, tr...
Hexokinase-2 Glycolytic Overload in Diabetes and Ischemia-Reperfusion Injury [0.03%]
糖尿病和缺血再灌注损伤中的己糖激酶-2糖酵解过载
Naila Rabbani,Paul J Thornalley
Naila Rabbani
Hexokinase-2 (HK2) was recently found to produce increased metabolic flux through glycolysis in hyperglycemia without concurrent transcriptional or other functional regulation. Rather, stabilization to proteolysis by increased glucose subst...