Soham Mukherjee,S N Suresh
Soham Mukherjee
Neuron-astrocyte crosstalk is a tightly regulated process that is essential for overall proper functioning of the brain. Maria S. Ioannou et al. (Cell, 2019) revealed a novel and compelling function of neuron-astrocyte crosstalk that explai...
Heterogeneity and Similarities in GLP-1 Receptor Agonist Cardiovascular Outcomes Trials [0.03%]
GLP-1受体激动剂心血管结局试验的异同点
Irene Caruso,Angelo Cignarelli,Francesco Giorgino
Irene Caruso
The latest recommendations from the American Diabetes Association and the European Association for the Study of Diabetes prioritize the use of drugs with proven cardiovascular (CV) benefit in patients with established CV disease. Especially...
Bennett Van Houten
Bennett Van Houten
A recent study by Polyzos et al. (Cell Metab., 2019) shows that astrocytes in a Huntington disease (HD) mouse model switch from glycolysis to fatty acid oxidation (FAO), causing increased superoxide radical anion production and loss of succ...
Aisan Farhadi,Massoud Vosough,Jin-San Zhang et al.
Aisan Farhadi et al.
Several conditions result in neurodegeneration; among which diabetes mellitus (DM) is of crucial importance. Tau (τ) malfunction is a major pathological process participating in neurodegeneration. Despite extensive considerations, the actu...
Michael Camilleri,Annamaria Staiano
Michael Camilleri
For the management of obesity in childhood and adolescence, nonoperative approaches have limited efficacy, including community-based and behavioral interventions and pharmacotherapy approved for use in adults. Roux-en-Y gastric bypass (RYGB...
Michael Camilleri,Annamaria Staiano
Michael Camilleri
For the management of obesity in childhood and adolescence, nonoperative approaches have limited efficacy, including community-based and behavioral interventions and pharmacotherapy approved for use in adults. Roux-en-Y gastric bypass (RYGB...
Efferocytosis and Atherosclerosis: Regulation of Phagocyte Function by MicroRNAs [0.03%]
细胞吞噬与动脉粥样硬化：microRNA对吞噬细胞功能的调节
Amir Tajbakhsh,Vanessa Bianconi,Matteo Pirro et al.
Amir Tajbakhsh et al.
There is evidence of the critical role of efferocytosis, the clearance of apoptotic cells (ACs) by phagocytes, in vascular cell homeostasis and protection against atherosclerosis. Specific microRNAs (miRs) can regulate atherogenesis by cont...
Efferocytosis and Atherosclerosis: Regulation of Phagocyte Function by MicroRNAs [0.03%]
咽唾颗粒吞噬与动脉粥样硬化：微小RNA介导的吞噬细胞功能调控
Amir Tajbakhsh,Vanessa Bianconi,Matteo Pirro et al.
Amir Tajbakhsh et al.
There is evidence of the critical role of efferocytosis, the clearance of apoptotic cells (ACs) by phagocytes, in vascular cell homeostasis and protection against atherosclerosis. Specific microRNAs (miRs) can regulate atherogenesis by cont...
Sisitha U Jayasinghe,Aurel T Tankeu,Francesca Amati
Sisitha U Jayasinghe
Skeletal muscle (SM) insulin resistance (IR) plays an important role in the burden of obesity, particularly because it leads to glucose intolerance and type 2 diabetes. Among the mechanisms thought to link IR to obesity is the accumulation,...
Takahito Miyake,Masao Doi
Takahito Miyake
Recently Koronowski et al. (Cell, 2019) showed that reconstitution of the liver circadian clock in otherwise genetically arrhythmic mice revives the daily program of the nicotinamide adenine dinucleotide salvage pathway and glycogenesis in ...