Gabriela Mercado,Patrik Brundin
Gabriela Mercado
A new mouse model of Parkinson's disease (PD) demonstrates α-synuclein pathology spreading from the gut to the brain via the vagus nerve (Kim et al., Neuron, 2019). The pathology is associated with motor and non-motor behavioral deficits i...
Romina P Grinspon,Analía V Freire,Rodolfo A Rey
Romina P Grinspon
The classical definition of hypogonadism, used in adult medicine, as gonadal failure resulting in deficient steroid and gamete production, and its classification into hypergonadotropic and hypogonadotropic refer to primary gonadal and hypot...
Ruben Quintana-Cabrera,Maria Eugenia Soriano
Ruben Quintana-Cabrera
Assembly factors are necessary for the formation of mitochondrial supercomplexes (SCs) and in making cellular respiration more efficient. In a recent study, Balsa et al. (Mol. Cell, 2019) report that nutrient-induced endoplasmic reticulum (...
Ghrelin-Mediated Hippocampal Neurogenesis: Implications for Health and Disease [0.03%]
胃泌素释放肽介导的海马神经发生：对健康和疾病的启示
Luke Buntwal,Martina Sassi,Alwena H Morgan et al.
Luke Buntwal et al.
There is a close relationship between cognition and nutritional status, however, the mechanisms underlying this relationship require elucidation. The stomach hormone, ghrelin, which is released during food restriction, provides a link betwe...
Zhiyong Cheng
Zhiyong Cheng
Autophagy controls cellular remodeling and quality control. Dysregulated autophagy has been implicated in several human diseases including obesity, diabetes, cardiovascular disease, neurodegenerative diseases, and cancer. Current evidence h...
Sarah L Chellappa,Nina Vujovic,Jonathan S Williams et al.
Sarah L Chellappa et al.
The circadian system, that is ubiquitous across species, generates ∼24 h rhythms in virtually all biological processes, and allows them to anticipate and adapt to the 24 h day/night cycle, thus ensuring optimal physiological function. Epid...
Nermeen N El-Agroudy,Anica Kurzbach,Roman N Rodionov et al.
Nermeen N El-Agroudy et al.
Nonalcoholic fatty liver disease (NAFLD) is becoming the most common liver disorder worldwide. Specifically, nonalcoholic steatohepatitis (NASH) and fibrosis pose an enormous burden for patients and health-care systems. In the absence of ap...
Hongsuk Park,Anyuan He,Irfan J Lodhi
Hongsuk Park
The global prevalence of obesity continues to increase, suggesting a need for alternative treatment approaches. Targeting brown fat function to promote energy expenditure represents one such approach. Brown adipocytes and the related beige ...
Handling Parathormone Receptor Type 1 in Skeletal Diseases: Realities and Expectations of Abaloparatide [0.03%]
掌管骨骼疾病中的甲状旁腺激素受体1：阿巴洛帕特 Ide 的现状与期望
Juan A Ardura,Sergio Portal-Núñez,Verónica Alonso et al.
Juan A Ardura et al.
Musculoskeletal disorders represent an elevated socioeconomic burden for developed aging societies. Osteoporosis (OP) has been treated with antiresorptive therapies or with teriparatide that was until recently the only anabolic therapy. How...
Alexander A Soukas,Haibin Hao,Lianfeng Wu
Alexander A Soukas
Metformin is the most widely prescribed oral hypoglycemic medication for type 2 diabetes worldwide. Metformin also retards aging in model organisms and reduces the incidence of aging-related diseases such as neurodegenerative disease and ca...