Tohru Hira,Jukkrapong Pinyo,Hiroshi Hara
Tohru Hira
Glucagon-like peptide-1 (GLP-1) is a gastrointestinal hormone released in response to meal ingestion and enhances insulin secretion from pancreatic β cells. In several human studies, GLP-1 secretory responses to oral glucose load or a meal...
NAFLD and Atherosclerosis: Two Sides of the Same Dysmetabolic Coin? [0.03%]
非酒精性脂肪肝和动脉粥样硬化是同一个代谢紊乱硬币的两面吗？
Daniela Stols-Gonçalves,G Kees Hovingh,Max Nieuwdorp et al.
Daniela Stols-Gonçalves et al.
The prevalence of non-alcoholic fatty liver disease (NAFLD) is strongly increasing and may put patients at increased risk for atherosclerotic cardiovascular disease (asCVD). Both disease phenotypes often co-occur, in the case of obesity, in...
Niloy Iqbal,LIang Zhu,Streamson C Chua Jr
Niloy Iqbal
Obesity is a neurological disorder that operates by favoring energy storage within adipose depots and increased caloric intake. Most cases of human obesity are acquired without any underlying genetic basis. Here, we suggest that obesity can...
Ying Wang,Siegfried Hekimi
Ying Wang
Ubiquinone (UQ, coenzyme Q) is an essential electron transfer lipid in the mitochondrial respiratory chain. It is a main source of mitochondrial reactive oxygen species (ROS) but also has antioxidant properties. This mix of characteristics ...
Clinical/Translational Aspects of Advanced Glycation End-Products [0.03%]
advanced glycation end-products的临床和转化方面
Chang Zeng,Yuanyuan Li,Jingzhi Ma et al.
Chang Zeng et al.
Advanced glycation end-products (AGEs) have been implicated in chronic hyperglycemia and age-related diseases. Endogenous AGEs produced by humans generate oxidative stress and activation of inflammatory signaling pathways via AGE-specific r...
Emerging Molecular Targets for Treatment of Nonalcoholic Fatty Liver Disease [0.03%]
非酒精性脂肪肝治疗新靶点研究进展
Ze Chen,Yao Yu,Jingjing Cai et al.
Ze Chen et al.
In parallel with the obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver disease worldwide. Disequilibrium of lipid metabolism and the subsequent metabolic-stress-induced inflammation are ...
Johan Fernø,Kristina Strand,Gunnar Mellgren et al.
Johan Fernø et al.
Adipose tissue macrophages (ATMs) orchestrate low-grade chronic adipose tissue inflammation, linking obesity and insulin resistance. Whereas factors contributing to macrophage accumulation in adipose tissue are established, little is known ...
Xin Li,Tingting Yang,Zheng Sun
Xin Li
'What doesn't kill you makes you stronger'. Hormesis, the paradoxical beneficial effects of low-dose stressors, can be better defined as the biphasic dose-effect or time-effect relationship for any substance. Here we review hormesis-like ph...
Maternal Microbiome and Metabolic Health Program Microbiome Development and Health of the Offspring [0.03%]
母体微生物组与代谢健康计划 微生物发育与子代健康
Marta Calatayud,Omry Koren,Maria Carmen Collado
Marta Calatayud
Maternal nutritional, metabolic, and physiological states, as well as exposure to various environmental factors during conception, gestation, and lactation, have a fundamental role in the health programming of the offspring. Therefore, alte...
Denis Burdakov,Daria Peleg-Raibstein
Denis Burdakov
Hypothalamic neurons implicated in energy homeostasis (Agrp, POMC, orexin, MCH) display fast, nutrient-independent dynamics. They do not simply mirror the slowly changing internal nutrient levels, but adapt rapidly to diverse external cues....