Temporally Tuned Corticosteroid Feedback Regulation of the Stress Axis [0.03%]
应激轴的糖皮质激素负反馈作用的时序调制机制研究
Joon S Kim,Karl J Iremonger
Joon S Kim
Activity of the hypothalamic-pituitary-adrenal (HPA) axis is tuned by corticosteroid feedback. Corticosteroids regulate cellular function via genomic and nongenomic mechanisms, which operate over diverse time scales. This review summarizes ...
Zahra Bahadoran,Parvin Mirmiran,Asghar Ghasemi
Zahra Bahadoran
Nitric oxide (NO) contributes to carbohydrate metabolism and decreased NO bioavailability is involved in the development of type 2 diabetes mellitus (T2DM). NO donors may improve insulin signaling and glucose homeostasis in T2DM and insulin...
Katya Frazier,Eugene B Chang
Katya Frazier
The gut microbiome and circadian rhythms (CRs) both exhibit unique influence on mammalian hosts and have been implicated in the context of many diseases, particularly metabolic disorders. It has become increasingly apparent that these syste...
Alexandre A Steiner,Andrej A Romanovsky
Alexandre A Steiner
Host defense relies not only on microbicidal mechanisms (resistance), but also on management of collateral damage (tolerance). Here, we discuss how this immunology concept converges with a physiology-born theory on the dichotomy of thermome...
Di Huang,Meng Deng,Shihuan Kuang
Di Huang
The global rise in the prevalence of obesity and affiliated metabolic syndrome poses a significant threat to human health. Various approaches, including bariatric surgery and pharmacotherapy, have been used in the clinical setting for obesi...
Takefumi Kikusui,Miho Nagasawa,Kensaku Nomoto et al.
Takefumi Kikusui et al.
Endocrine system regulation is important for the maintenance of homeostasis; it controls hormonal functions in complex physiology and behavior and adaptations to social environments. Evidence indicates that for more than 35 000 years, dogs ...
Philibert Duriez,Nicolas Ramoz,Philip Gorwood et al.
Philibert Duriez et al.
Anorexia nervosa (AN) is the psychiatric disorder with the highest mortality rate; however, the mechanisms responsible for its pathogenesis remain largely unknown. Large-scale genome-wide association studies (GWAS) have identified genetic l...
A Tale of Two Proteins: Betaglycan, IGSF1, and the Continuing Search for the Inhibin B Receptor [0.03%]
别加甘кан和IGSF1蛋白：寻觅抑制素B受体的故事
Daniel J Bernard,Courtney L Smith,Emilie Brûlé
Daniel J Bernard
Inhibins are gonadal hormones that suppress follicle-stimulating hormone (FSH) synthesis by pituitary gonadotrope cells. The structurally related activins stimulate FSH by signaling through complexes of type I and type II receptors. Two mod...
Alfonso Abizaid,James L Hougland
Alfonso Abizaid
Ghrelin and the growth hormone secretagogue receptor 1a (GHS-R1a) are important targets for disorders related to energy balance and metabolic regulation. Pharmacological control of ghrelin signaling is a promising avenue to address health i...