Nathaniel F Henneman,Ganna Panasyuk
Nathaniel F Henneman
Fasting is a recurrent daily energy stress that benefits healthspan and lifespan. While ketones fuel fasting in vertebrates, the underlying transcriptional mechanism remains incompletely understood. Recently, Korenfeld et al. revealed perox...
Myeloid-derived suppressor cells in metabolic and cardiovascular disorders [0.03%]
代谢和心血管疾病中的髓源性抑制细胞
Jingwei Yan,Shuai Guo,Jun He et al.
Jingwei Yan et al.
Dysregulation of immune homeostasis can precipitate chronic inflammation, thus significantly contributing to the onset and progression of metabolic and cardiovascular diseases. Myeloid-derived suppressor cells (MDSCs) constitute a heterogen...
Hallmarks of ovarian aging [0.03%]
卵巢老化的特征
Chuqing Wu,Dan Chen,Michael B Stout et al.
Chuqing Wu et al.
Ovarian aging is considered to be the pacemaker of female aging, and is linked to various comorbidities such as osteoporosis, cardiovascular diseases, and cognitive decline. Many efforts have been made to determine the mechanisms underlying...
Insights from omics research on plant-based diets and cardiometabolic health [0.03%]
基于宏基因组学研究的植物性饮食与心代谢健康的见解
Hyunju Kim,Casey M Rebholz
Hyunju Kim
Plant-based diets emphasize higher intake of plant foods and are low in animal products. Individuals following plant-based diets have a lower risk of chronic conditions; however, the mechanisms underlying these associations are not complete...
Prediabetes remission to reduce the global burden of type 2 diabetes [0.03%]
糖尿病前期的缓解以减轻全球2型糖尿病的疾病负担
Leontine Sandforth,Stephanie Kullmann,Arvid Sandforth et al.
Leontine Sandforth et al.
Prediabetes is a highly prevalent and increasingly common condition affecting a significant proportion of the global population. The heterogeneous nature of prediabetes presents a challenge in identifying individuals who particularly benefi...
Do weight loss interventions challenge the obesity paradox in heart failure? [0.03%]
体重减轻干预会挑战心力衰竭中的肥胖悖论吗？
Salva R Yurista,Robert A Eder,W Scott Butsch et al.
Salva R Yurista et al.
Cardiovascular disease (CVD) remains a significant global health concern, with obesity recognized as a prominent risk factor. The 'obesity paradox' (OP) suggests that obesity does not always lead to adverse outcomes, particularly in heart f...
Samuel Daniels,Cecilia Karlsson,Patrick Schrauwen et al.
Samuel Daniels et al.
Identification of exendin-4 (a glucagon-like peptide 1 receptor agonist, GLP-1RA) in Gila monster venom may be regarded as one of the most serendipitous discoveries of recent times. GLP-1RAs are now an established therapeutic approach in ty...
Subcellular mitochondrial heterogeneity enables opposing metabolic demands [0.03%]
亚细胞线粒体异质性可满足相反的代谢需求
Brandon Chen,Yatrik M Shah,Costas A Lyssiotis
Brandon Chen
Mitochondria perform essential metabolic processes that sustain cellular bioenergetics and biosynthesis. In a recent article, Ryu et al. explored how mitochondria coordinate biochemical reactions with opposing redox demands within the same ...
Atrayee Gope,Claudio Mauro
Atrayee Gope
Lineage tracing of pancreatic cells for mechanistic and therapeutic insights [0.03%]
谱系追踪胰腺细胞以获得机理和治疗学见解
Huan Zhao,Bin Zhou
Huan Zhao
Recent advances in lineage-tracing technologies have significantly improved our understanding of pancreatic cell biology, particularly in elucidating the ontogeny and regenerative capacity of pancreatic cells. A deeper appreciation of the m...