Hong Yang,Xiangtai Kong,Xinmeng Liao et al.
Hong Yang et al.
Mitochondria play a central role in energy metabolism, redox balance, and cellular homeostasis, and their dysfunction has been implicated in the pathogenesis of complex human diseases. Advances in systems biology and omics technologies have...
Seow Neng Chan,Jun Wei Pek
Seow Neng Chan
The ovary is more than just a reproductive organ. Recent evidence in mammalian and invertebrate models consistently highlights novel mechanistic insights into organ-ovary crosstalk via classical hormones and emerging secretomes, such as ext...
The reciprocal endothelium-adipose loop fuels cardiometabolic diseases [0.03%]
互为因果的内皮细胞-脂肪组织循环促使心血管代谢性疾病发病
Chak Kwong Cheng,Stefan Offermanns,Yu Huang
Chak Kwong Cheng
Vasculature and surrounding adipose tissue constitute a dynamic interface, maintaining cardiometabolic homeostasis. Obesity rewires this crosstalk into a self-perpetuating cycle. Two recent studies by Suda et al. and Hof et al., respectivel...
Reversible phosphorylation influences energetic cellular metabolism by modulating mitochondrial gene expression [0.03%]
可逆磷酸化通过调节线粒体基因表达影响细胞代谢
Aldara Mainé-Rodrigo,Ana Vela-Sebastián,David Pacheu-Grau
Aldara Mainé-Rodrigo
Mitochondria act as key metabolic regulators beyond ATP production, and the understanding of how cellular signaling modifies mitochondrial gene expression is currently being explored. Recent evidence links kinases such as mitogen-activated ...
Min Fu,Yusha Zhao,Dingjiacheng Jia
Min Fu
Microbes can extensively regulate the physiological or pathological processes of host organs by secreting metabolites. Recently, Zhang et al. demonstrated that ectopic Catenibacterium mitsuokai could secrete quinolinic acid, activating the ...
Yue Zhang,Yan Tian,Xianghui Fu
Yue Zhang
The metabolite substrates of numerous transporters remain largely elusive. Two recent studies by Khan et al. and Dias et al. identify SLC25A45 as a mitochondrial transporter of methylated amino acids that supports de novo carnitine synthesi...
Junlin Wei,Yanwei Luo,Fang Wang
Junlin Wei
Skin vascular aging is characterized by a specific loss of capillary-associated macrophages (CAMs), driven by impaired local proliferation. This depletion causes microvascular dysfunction. Restoring CAMs via colony-stimulating factor 1 stim...
Timo D Müller,David A D&#x;Alessio,Jonathan E Campbell
Timo D Müller
Ziyan Xia,Zhaoyi Li,Peng Jiang
Ziyan Xia
Through metabolic remodeling, tumor cells can modulate neighboring CD8+ T cell function via metabolites. A recent study by Ma et al., published in Immunity, reveals that tumor-cell-derived succinate exhibits an antitumor immune effect, prom...
Mauricio Castro-Sepulveda
Mauricio Castro-Sepulveda
Emerging evidence suggests an interplay between the molecular clock and mitochondrial dynamics in skeletal muscle. In this Forum article, we hypothesize that exercise, as a metabolic challenge, provides a powerful physiological model to inv...