Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy [0.03%]
褪黑素对葡萄糖代谢的影响：是时候揭开争议了
Marta Garaulet,Jingyi Qian,Jose C Florez et al.
Marta Garaulet et al.
The past decade has witnessed a revival of interest in the hormone melatonin, partly attributable to the discovery that genetic variation in MTNR1B - the melatonin receptor gene - is a risk factor for impaired fasting glucose and type 2 dia...
Uterine Luminal Epithelium as the Transient Gateway for Embryo Implantation [0.03%]
子宫腔内上皮作为胚胎植入的暂行通道
Xiaoqin Ye
Xiaoqin Ye
The uterine luminal epithelium (LE) is the first maternal contact for an implanting embryo. Intrauterine fluid resorption, cessation of LE proliferation and apoptosis, and LE structural changes are prerequisites for establishing transient u...
Todd H Kimball,Thomas M Vondriska
Todd H Kimball
Eukaryotes must balance the metabolic and cell death actions of mitochondria via control of gene expression and cell fate by chromatin, thereby functionally binding the metabolome and epigenome. This interaction has far-reaching implication...
Claudia Bambs,Roberto Bravo-Sagua,Paula Margozzini et al.
Claudia Bambs et al.
Chile has experienced rapid epidemiological transitions characterized by decreasing infant mortality, population aging, and a shift towards obesity with an increase in noncommunicable diseases (NCDs). Today, tobacco, alcohol, and ultraproce...
Mineralocorticoid Receptors in Metabolic Syndrome: From Physiology to Disease [0.03%]
代谢综合征中的盐皮质激素受体研究：从生理到疾病
Alessandra Feraco,Vincenzo Marzolla,Angelo Scuteri et al.
Alessandra Feraco et al.
Over the past decade, several studies have shown that activity of extra-renal mineralocorticoid receptors (MR) regulates vascular tone, adipogenesis, adipose tissue function, and cardiomyocyte contraction. In mice, abnormal activation of MR...
Endocrinological Toxicity Secondary to Treatment of Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs) [0.03%]
胃肠胰神经内分泌肿瘤(GEP-NENs)治疗引起的内分泌毒性
Krystallenia I Alexandraki,Kosmas Daskalakis,Marina Tsoli et al.
Krystallenia I Alexandraki et al.
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are increasingly recognized, characterized by prolonged survival even with metastatic disease. Their medical treatment is complex involving various specialties, necessitating awaren...
Role of Lipoproteins in the Microenvironment of Hormone-Dependent Cancers [0.03%]
脂蛋白在激素依赖性癌症微环境中的作用
Monica Gomaraschi
Monica Gomaraschi
The tumor microenvironment (TME) is an attractive target to develop novel strategies for hormone-dependent cancers. Several molecules in the TME can favor tumor development and progression, including lipoproteins. Lipoproteins are taken up ...
Jennifer R Snaith,Deborah J Holmes-Walker,Jerry R Greenfield
Jennifer R Snaith
Individuals with type 1 diabetes (T1D) frequently fail to achieve glycemic goals and have excess cardiovascular risk and premature death. Adjunctive agents may play a role in reducing morbidity, mortality, and the adverse sequelae of insuli...
Jingjing Qian,Qi Chen,Sean M Ward et al.
Jingjing Qian et al.
Epidemiological studies have revealed that caffeine consumption during pregnancy is associated with adverse gestational outcomes, yet the underlying mechanisms remain obscure. Recent animal studies with physiologically relevant dosages have...
Coronary Microvascular Dysfunction and Estrogen Receptor Signaling [0.03%]
冠状微血管功能不全与雌激素受体信号转导路径之间的关系
Elif Tunc,Alicia Arredondo Eve,Zeynep Madak-Erdogan
Elif Tunc
Chest pain with non-obstructive coronary artery disease (NOCAD) occurs more frequently in women than in men and is mainly related to coronary microvascular disease (CMD). The majority of CMD patients are postmenopausal women, suggesting a r...