Mitochondrial Complex I Inhibition by Metformin: Drug-Exercise Interactions [0.03%]
二甲双胍通过抑制线粒体复合物I与运动的相互作用
S Martín-Rodríguez,P de Pablos-Velasco,J A L Calbet
S Martín-Rodríguez
Metformin has antidiabetic, anticancer, and prolongevity effects, but seems to interfere with aerobic training mitochondrial adaptations. The primary mechanism of action has been suggested to be the inhibition of mitochondrial complex I. Re...
Yazmín Macotela,Jakob Triebel,Carmen Clapp
Yazmín Macotela
The pituitary hormone prolactin (PRL) regulates a variety of functions beyond reproduction. The association between physiological (pregnancy) and pathological (prolactinoma) hyperprolactinemia and metabolic alterations led to the concept of...
Glucocorticoid Sexual Dimorphism in Metabolism: Dissecting the Role of Sex Hormones [0.03%]
糖皮质激素在代谢中的性别二态性：剖析性激素的作用
Jan Kroon,Alberto M Pereira,Onno C Meijer
Jan Kroon
Glucocorticoids are steroid hormones that are of pivotal importance in human physiology. Glucocorticoid signaling is complex in nature and dependent on many interacting factors. As glucocorticoids exhibit sexually dimorphic effects on sever...
Michaela C Pascoe,David R Thompson,Chantal F Ski
Michaela C Pascoe
Meditation is a popular practice for reducing stress and improving mental health and wellbeing. Its effects are mediated largely by the endocrine system, including the hypothalamic-pituitary-adrenal axis, the hypothalamic-pituitary-thyroid ...
Wharton's Jelly MSCs: Potential Weapon to Sharpen for Our Battle against DM [0.03%]
沃顿胶间充质干细胞：对抗糖尿病的潜力武器
Dina H Kassem,Mohamed M Kamal
Dina H Kassem
Diabetes mellitus (DM) is a devastating metabolic disease. Stem cell therapy provides great hope to all diabetic patients. Umbilical cord (UC) Wharton's jelly mesenchymal stem cells (WJ-MSCs) specifically provides a potential cell therapy f...
Thiago Matos de Araújo,Licio A Velloso
Thiago Matos de Araújo
Genome-wide association studies (GWASs) have identified SNPs of the fat mass and obesity (FTO) gene as the most important risk alleles for obesity. However, how the presence of risk alleles affect phenotype is still a matter of intense inve...
Paola Viganò,Alessandra Alteri,Andrea Busnelli et al.
Paola Viganò et al.
Controlled ovarian hyperstimulation (COH) determines an anticipation of endometrial maturation and a premature occurrence of the implantation window, as shown by histological, histochemical, and molecular studies and indirectly by clinical ...
María Sánchez-Díaz,José Ángel Nicolás-Ávila,Mario D Cordero et al.
María Sánchez-Díaz et al.
The heart pumps blood throughout the whole life of an organism, without rest periods during which to replenish energy or detoxify. Hence, cardiomyocytes, the working units of the heart, have mechanisms to ensure constitutive production of e...
A Novel Role for CETP as Immunological Gatekeeper: Raising HDL to Cure Sepsis? [0.03%]
新型细胞胆固醇转运蛋白作为免疫调节因子的作用机制：升高HDL水平可治疗脓毒血症吗？
Lisanne L Blauw,Yanan Wang,Ko Willems van Dijk et al.
Lisanne L Blauw et al.
Raising HDL using cholesteryl ester transfer protein (CETP) inhibitors failed to show a clinically relevant risk reduction of cardiovascular disease in clinical trials, inviting reconsideration of the role of CETP and HDL in human physiolog...
Dídac Mauricio,Núria Alonso,Mònica Gratacòs
Dídac Mauricio
Chronic-diabetes-related complications simultaneously compromise both the micro- and macrovascular trees, with target organs considered as the paradigm of large vessel injury also entailing microangiopathic changes. However, complications i...