Familial Hypercholesterolemia and Atherosclerosis: Animal Models and Therapeutic Advances [0.03%]
家族性高胆固醇血症和动脉粥样硬化：动物模型与治疗进展
Suowen Xu,Jianping Weng
Suowen Xu
Familial hypercholesterolemia (FH), mainly arising from loss-of-function mutation of the low-density lipoprotein receptor (LDLR), is a life-threatening inherited cardiometabolic disorder with limited therapies. In a recent study, Zhao et al...
Trine Moholdt,John A Hawley
Trine Moholdt
About one-third of women of reproductive age are obese, predisposing both mother and baby to unfavourable pregnancy outcomes and initiating an intergenerational cycle of chronic metabolic disorders. Here we summarise recent research on the ...
Gut Microbial Metabolites of Aromatic Amino Acids as Signals in Host-Microbe Interplay [0.03%]
芳香族氨基酸肠道菌群代谢产物在宿主-微生物互作中的信号作用
Yali Liu,Yuanlong Hou,Guangji Wang et al.
Yali Liu et al.
Gut microbial metabolism is intimately coupled with host health and disease. Aromatic amino acid (AAA) catabolism by the gut microbiome yields numerous metabolites that may regulate immune, metabolic, and neuronal responses at local and dis...
Gut Microbiome and Radioiodine-Refractory Papillary Thyroid Carcinoma Pathophysiology [0.03%]
肠道菌群与放射性碘难治性乳头状甲状腺癌发病机制的关系
Hilda Samimi,Vahid Haghpanah
Hilda Samimi
Gut microbiome (GM) might be associated with radioiodine (RAI)-refractory papillary thyroid carcinoma (PTC) through different mechanisms related to sodium/iodide (Na+/I-) symporter (NIS) regulation. However, whether thyroid carcinoma (TC), ...
Mitochondria and T2D: Role of Autophagy, ER Stress, and Inflammasome [0.03%]
线粒体与2型糖尿病：自噬、内质网应激及炎性小体的功能作用
Milagros Rocha,Nadezda Apostolova,Ruben Diaz-Rua et al.
Milagros Rocha et al.
Type 2 diabetes (T2D) is one of the main current threats to human health. Both T2D and its numerous clinical complications are related to mitochondrial dysfunction and oxidative stress. Over the past decade, great progress has been made in ...
Jeremy Gingrich,Elvis Ticiani,Almudena Veiga-Lopez
Jeremy Gingrich
Endocrine disrupting chemicals (EDCs) are chemicals that can interfere with normal endocrine signals. Human exposure to EDCs is particularly concerning during vulnerable periods of life, such as pregnancy. However, often overlooked is the e...
Giovanna Muscogiuri,Luigi Barrea,Tiziana Feola et al.
Giovanna Muscogiuri et al.
Genetic and molecular disparities between men and women have a role in the differing incidence, pathophysiology, clinical signs, and treatment outcome of several cancers. Sex differences in cancer incidence are attributed to regulation at t...
Bruno Vergès
Bruno Vergès
Type 1 diabetes (T1D) patients show lipid disorders which are likely to play a role in their increased cardiovascular (CV) disease risk. Quantitative abnormalities of lipoproteins are noted in T1D with poor glycemic control. In T1D with opt...
Müller Cell Metabolic Signatures: Evolutionary Conservation and Disruption in Disease [0.03%]
Müller细胞代谢谱型：进化保守性和疾病的破坏作用
Rebecca L Pfeiffer,Robert E Marc,Bryan W Jones
Rebecca L Pfeiffer
Müller cells are glia that play important regulatory roles in retinal metabolism. These roles have been evolutionarily conserved across at least 300 million years. Müller cells have a tightly locked metabolic signature in the healthy reti...
Andrea Giustina
Andrea Giustina
Here I review vertebral fractures (VFs) as an emerging complication of acromegaly through a pathway of key questions in order to help clinicians manage the disease. Peculiarities of acromegalic osteopathy are that VFs are common but not exp...