Fabio Facchinetti,Vittorio Unfer,Didier Dewailly et al.
Fabio Facchinetti et al.
This review details the physiologic roles of two insulin sensitizers, myo-inositol (MI) and d-chiro-inositol (DCI). In the human ovary, MI is a second messenger of follicle-stimulating hormone (FSH) and DCI is an aromatase inhibitor. These ...
Ricardo J Samms,Matthew P Coghlan,Kyle W Sloop
Ricardo J Samms
Glucagon-like peptide-1 (GLP-1) receptor agonists improve glucose homeostasis, reduce bodyweight, and over time benefit cardiovascular health in type 2 diabetes mellitus (T2DM). However, dose-related gastrointestinal effects limit efficacy,...
Debunking the Myth of the Endogenous Antiangiogenic Vegfaxxxb Transcripts [0.03%]
破解VEGFAxxxB转录的内源性抗血管生成的神话
Hugues Dardente,William R English,Manoj K Valluru et al.
Hugues Dardente et al.
In this opinion article we critically assess evidence for the existence of a family of antiangiogenic vascular endothelial growth factor (Vegfaxxxb) transcripts, arising from the use of a phylogenetically conserved alternative distal splice...
Mohammed K Hankir,Florian Seyfried
Mohammed K Hankir
Leptin-based obesity pharmacotherapies were originally developed according to the lipostatic view that elevated circulating leptin levels promote a negative energy balance. A series of independent preclinical findings suggest, however, that...
Amy K Sutton,Michael J Krashes
Amy K Sutton
Motivated behaviors have fascinated neuroscientists and ethologists for decades due to their necessity for organism survival. Motivations guide behavioral choice through an intricate synthesis of internal state detection, external stimulus ...
Valeria Hasenmajer,Emilia Sbardella,Francesca Sciarra et al.
Valeria Hasenmajer et al.
Cushing's syndrome (CS), or chronic hypercortisolism, induces a variety of alterations in the immune system, often leading to severe clinical complications such as sepsis and opportunistic infections. Prolonged exposure to high levels of gl...
Shuai Jiang
Shuai Jiang
Angiari et al. recently reported that TEPP-46 induces PKM2 tetramerization, thereby inhibiting its nuclear translocation and suppressing CD4+ T cell activation, T helper (Th)1/Th17 cell development, and experimental autoimmune encephalomyel...
CREDENCE: Significant Victory for Diabetic Kidney Disease [0.03%]
周效胰岛素联合利拉鲁肽治疗2型糖尿病合并慢性肾脏病患者疗效及安全性研究
Ashish Verma,Ankit B Patel,Ashish Upadhyay et al.
Ashish Verma et al.
Diabetic kidney disease (DKD), the most common cause of end-stage kidney disease (ESKD), has significant morbidity and mortality, particularly from cardiovascular complications. The CREDENCE (canagliflozin and renal events in diabetes with ...
Trained Immunity: Linking Obesity and Cardiovascular Disease across the Life-Course? [0.03%]
训练免疫：一生当中连接肥胖和心血管疾病的关键？
Siroon Bekkering,Christoph Saner,Niels P Riksen et al.
Siroon Bekkering et al.
Obesity, a chronic inflammatory disease, is the most prevalent modifiable risk factor for cardiovascular disease. The mechanisms underlying inflammation in obesity are incompletely understood. Recent developments have challenged the dogma o...
Carsten Schmitz-Peiffer
Carsten Schmitz-Peiffer
The failure of insulin to suppress glucose production by the liver is a key aspect of the insulin resistance seen in type 2 diabetes. Lipid-activated protein kinase C epsilon has long been identified as an important mediator of diet-induced...