Stephanie E King,Michael K Skinner
Stephanie E King
The prevalence of obesity and associated diseases has reached pandemic levels. Obesity is often associated with overnutrition and a sedentary lifestyle, but clearly other factors also increase the susceptibility of metabolic disease states....
Juan Pablo Del Río,Santiago Molina,Oscar Hidalgo-Lanussa et al.
Juan Pablo Del Río et al.
Tibolone (TIB), a selective tissue estrogenic activity regulator (STEAR) in clinical use by postmenopausal women, activates hormonal receptors in a tissue-specific manner. Estrogenic activity is present mostly in the brain, vagina, and bone...
Handuo Shi,Kerwyn Casey Huang
Handuo Shi
Despite their small sizes, bacterial cells within a host-associated microbial community often form highly structured complexes determined by environmental factors and interspecies interactions. Wilbert et al. combined species-specific fluor...
Ashley M Sidebottom,Eugene B Chang
Ashley M Sidebottom
Gut microbiota shape the metabolome which then directly impacts host physiology. Sinha et al. observe and suggest that decreases in the levels of Ruminococcaceae and secondary bile acids (SBAs) contribute to pouchitis in ulcerative colitis ...
Bruce R Hamaker,Thaisa Moro Cantu-Jungles
Bruce R Hamaker
Supplementation with resistant starches of different structures led to divergent shifts in key bacterial taxa abundance and distinct butyrate or propionate outcomes. A recent randomized controlled trial (RCT) reported by Deehan et al. showe...
Vinicius Kannen,Michael Bader,Juliana Y Sakita et al.
Vinicius Kannen et al.
Serotonin (5-HT) has complex effects on the central nervous system (CNS), neuroendocrine mechanisms, immunological reactions, intestinal microbiome, and cancer. It has been associated with more severe signs and symptoms of colitis, as well ...
Breakthroughs in the Use of Inositols for Assisted Reproductive Treatment (ART) [0.03%]
肌醇在辅助生殖技术中的应用进展
Fabio Facchinetti,Maria Salome Bezerra Espinola,Didier Dewailly et al.
Fabio Facchinetti et al.
It is well known that myo-inositol (MI) and D-chiro-inositol (DCI) are insulin-sensitizing agents, and MI is of proven utility in polycystic ovary syndrome (PCOS). In addition, MI plays a pivotal role in the physiology of reproduction, and ...
Zhengxiang Huang,Lili Huang,Michael J Waters et al.
Zhengxiang Huang et al.
Disruption of endocrine hormonal balance (i.e., increased levels of insulin, and reduced levels of growth hormone, GH) often occurs in pre-obesity and obesity. Using distinct intracellular signaling pathways to control cell and body metabol...
Clara B Peek
Clara B Peek
Research over the past few decades has shed light on the mechanisms underlying the link between circadian disruption and the development of metabolic diseases such as obesity, type 2 diabetes, and cancer. However, how the clock network inte...
Nanomedicine-Based Strategies for Diabetes: Diagnostics, Monitoring, and Treatment [0.03%]
基于纳米医学的糖尿病诊疗策略：诊断、监测和治疗
Luke R Lemmerman,Devleena Das,Natalia Higuita-Castro et al.
Luke R Lemmerman et al.
Traditional methods for diabetes management require constant and tedious glucose monitoring (GM) and insulin injections, impacting quality of life. The global diabetic population is expected to increase to 439 million, with approximately US...