Key Metabolic Functions of β-Arrestins: Studies with Novel Mouse Models [0.03%]
β-arrestin的关键代谢功能：新型小鼠模型的研究
Sai P Pydi,Luiz F Barella,Jaroslawna Meister et al.
Sai P Pydi et al.
β-Arrestin-1 and -2 are intracellular proteins that are able to inhibit signaling via G protein-coupled receptors (GPCRs). However, both proteins can also modulate cellular functions in a G protein-independent fashion. During the past few ...
Skin Metabolomics [0.03%]
皮肤代谢组学
Decibel P Elpa,Hsien-Yi Chiu,Shu-Pao Wu et al.
Decibel P Elpa et al.
Skin retains numerous low-molecular-weight compounds (metabolites). Some of these compounds fulfill specific physiological roles, while others are by-products of metabolism. The skin surface can be sampled to detect and quantify skin metabo...
Michael Blatzer,Nicolas Papon,Yves Delneste et al.
Michael Blatzer et al.
It is well known that the intestine absorbs nutrients, electrolytes, and water. Chikina et al. recently demonstrated that it is also able to sense, recognize, and block the absorption of toxins through a very sophisticated interactive cellu...
Flavonoids in Bone Erosive Diseases: Perspectives in Osteoporosis Treatment [0.03%]
骨侵蚀性疾病中的黄酮类化合物：绝经后妇女骨质疏松症治疗的展望
Daniele Bellavia,Eufrosina Dimarco,Viviana Costa et al.
Daniele Bellavia et al.
Imbalance of bone homeostasis, with excessive bone resorption compared with bone formation, leads to the development of progressive osteopenia leading to lower bone resistance to load, with consequent pain and functional limitations. Phytoc...
Nutritional Control of Intestinal Stem Cells in Homeostasis and Tumorigenesis [0.03%]
营养调控肠道干细胞介肠黏膜稳态和肿瘤发生中的作用机制研究
Gizem Calibasi-Kocal,Omid Mashinchian,Yasemin Basbinar et al.
Gizem Calibasi-Kocal et al.
Food and nutrition have a profound impact on organismal health and diseases, and tissue-specific adult stem cells play a crucial role in coordinating tissue maintenance by responding to dietary cues. Emerging evidence indicates that adult i...
Shuangcheng Alivia Wu,Sander Kersten,Ling Qi
Shuangcheng Alivia Wu
Lipoprotein lipase (LPL) is one of the most important factors in systemic lipid partitioning and metabolism. It mediates intravascular hydrolysis of triglycerides packed in lipoproteins such as chylomicrons and very-low-density lipoprotein ...
Melissa L Brown,Alan Schneyer
Melissa L Brown
In 2010, we published a review summarizing the role of the transforming growth factor-beta (TGFβ) family of proteins in diabetes. At that time there were still many outstanding questions that needed to be answered. In this updated review, ...
Sharon Baumel-Alterzon,Liora S Katz,Gabriel Brill et al.
Sharon Baumel-Alterzon et al.
Prolonged hyperglycemia is toxic to pancreatic β cells, generating excessive reactive oxygen species, defective glucose-stimulated insulin secretion, decreased insulin production, and eventually β cell death and diabetes. Nrf2 is a master...
Graziano Pinna
Graziano Pinna
Evidence shows coronavirus disease 2019 (COVID-19)-induced symptom severity and mortality is more frequent in men than in women, suggesting sex steroids may play a protective role. Female reproductive steroids, estrogen and progesterone, an...