Lamin A/C in health, laminopathies, and familial partial lipodystrophy 2 [0.03%]
核纤层蛋白A/C的结构与功能及其在健康状态、核纤层病及家族性部分脂肪营养不良症中的作用
Jessica N Maung,Elif A Oral,Ormond A MacDougald
Jessica N Maung
Familial partial lipodystrophy 2 (FPLD2) is a rare disease characterized by selective adipose tissue loss, expansion, and dysfunction, caused by pathogenic variants in LMNA encoding nuclear lamins A and C. Here, we synthesize current eviden...
Shijia Pan,Liwen Zhang,Yunfang Zhang et al.
Shijia Pan et al.
RNA modifications constitute a dynamic regulatory code governing RNA structure, fate, and translation. Modified nucleosides, long dismissed as metabolic waste, are now recognized as stable biomarkers and active signaling messengers involved...
Sebastian J Hofer,Anna Katharina Simon,Frank Madeo
Sebastian J Hofer
Metabolomes change with age. Yet, fluxomics points to a contradiction: Jankowski et al. in Cell Metabolism report shifts in metabolite concentrations in aged mice, alongside largely preserved metabolite fluxes, evoking important questions o...
Anlei Li,Hao Huang,Rong Xiang
Anlei Li
Addressing endocrine resistance in hormone receptor-positive breast cancer, Padrão et al. identify the glucocorticoid receptor (GR) as the key transducer of fasting benefits. They demonstrate that pharmacological GR activation recapitulate...
Yazmín Macotela,Gonzalo Martínez de la Escalera,Carmen Clapp
Yazmín Macotela
Gauri Mirji,Sajad Ahmad Bhat,Rahul S Shinde
Gauri Mirji
Trimethylamine-N-oxide (TMAO), a gut microbial metabolite derived from dietary choline and carnitine, has emerged as a pivotal link between diet, microbial metabolism, and host immunity. Beyond its historical role as a marine osmolyte, TMAO...
Lara Albert,Ismael Capel,Mercedes Rigla
Lara Albert
Continuous glucose monitoring (CGM) has become standard care in type 1 diabetes, yet the key measures used to interpret CGM data, such as time spent within, below, or above the target glucose range, and glycemic variability, remain based on...
Jia Liu,Rui Kang,Daolin Tang
Jia Liu
Heme availability shapes mitochondrial function, redox balance, and innate immune signaling. Recent studies reveal threshold-dependent heme states that predispose cells to cuproptosis, ferroptosis, apoptosis, pyroptosis, or PANoptosis. View...
Communication breakdown: senescent cells in interorgan communication of aging [0.03%]
通讯中断：衰老器官间相互作用中的衰老细胞
Rituparna Ghosh,Shweta S Dipali,Gabriela Desdín-Míco et al.
Rituparna Ghosh et al.
Cellular senescence is a complex cell fate characterized by stable cell cycle arrest and other heterogeneous changes. Senescent cells play a causal role in aging, although the underlying mechanisms remain under active investigation. In this...
Gut dysbiosis-mediated platelet activation as MASLD and cardiovascular disease link [0.03%]
肠道菌群失调介导的血小板活化是MASLD和心血管疾病联系的纽带
Francesco Violi,Pasquale Pignatelli,Roberto Carnevale et al.
Francesco Violi et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by liver disease progression and cardiovascular disease (CVD). The mechanism linking MASLD with CVD is not fully understood. Here, we report experimental and ...