Advancing precision medicine in metabolic dysfunction-associated steatotic liver disease [0.03%]
代谢功能紊乱相关肝脂质沉积病精准医学的研究进展
Bryan A Priego-Parra,Rocío Gallego-Durán,Berenice M Román-Calleja et al.
Bryan A Priego-Parra et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), has become a pressing global health concern. The complexity of MASLD and the lack of universally effective treatme...
Meng Yuan,Mengnan Shi,Hong Yang et al.
Meng Yuan et al.
Pyruvate kinase is a key regulator in hepatic glucose metabolism, encoded by the gene pyruvate kinase liver/red blood cells (PKLR). Systems biology-based approaches, including metabolic and gene co-expression networks analyses, as well as g...
María F Andreoli,Pablo N De Francesco,Mario Perelló
María F Andreoli
Keyu Su,Deshun Zeng,Weiru Zhang et al.
Keyu Su et al.
Circadian rhythms are cell-intrinsic time-keeping mechanisms that allow organisms to adapt to 24-h environmental changes, ensuring coordinated physiological functions by aligning internal metabolic oscillations with external timing cues. Di...
Julie Bakker
Julie Bakker
The neuropeptide kisspeptin activates the hypothalamic-pituitary-gonadal (HPG) axis and influences neural circuits controlling sexual behavior. Animal studies have determined its sex-specific roles in reproductive behaviors, whereas human r...
Amy S Shah,Megan M Kelsey,Risa M Wolf et al.
Amy S Shah et al.
Youth-onset type 2 diabetes (YO-T2D) is an urgent public health challenge that demands immediate and innovative action. The devastating trajectory of this disease - from rapid β-cell decline to early complications and poor responses to med...
Ruilong Liu,Yingming Zhao
Ruilong Liu
Hidden players in the metabolic vulnerabilities of amyotrophic lateral sclerosis [0.03%]
肌萎缩侧索硬化代谢脆弱性的隐藏参与者
Marco Rosina,Silvia Scaricamazza,Gianmarco Fenili et al.
Marco Rosina et al.
Amyotrophic lateral sclerosis (ALS) is a complex and rapidly progressive motor neuron disorder with a fatal outcome. Despite the remarkable progress in understanding ALS pathophysiology, which has significantly contributed to clinical trial...
Dídac Mauricio,Mònica Gratacòs,Josep Franch-Nadal
Dídac Mauricio
Hormonal fluctuations across the female reproductive lifespan lead to physiological adjustments that impact insulin sensitivity and glucose metabolism, generating unique challenges in diabetes management. Although current guidelines focus p...
Alessandro Giollo,Mariangela Salvato,Andrea Doria
Alessandro Giollo