Old Paradoxes and New Opportunities for Appetite Control in Obesity [0.03%]
肥胖症的摄食控制 old paradoxes and new opportunities
Léa Montégut,Carlos Lopez-Otin,Christophe Magnan et al.
Léa Montégut et al.
Human obesity is accompanied by alterations in the blood concentrations of multiple circulating appetite regulators. Paradoxically, most of the appetite-inhibitory hormones are elevated in nonsyndromic obesity, while most of the appetite st...
Jean-Marc Collard,Philippe Sansonetti,Nicolas Papon
Jean-Marc Collard
Our gut microbiota is known as an efficient barrier for infection; however, the physiological processes involved are poorly understood. Stacy et al. recently shed light on the key contribution of taurine to the trainable resistance of the g...
From Pharmacology to Physiology: Endocrine Functions of μ-Opioid Receptor Networks [0.03%]
从药理学到生理学：μ-阿片受体网络的内分泌功能
Nikolai Jaschke,Sophie Pählig,Ying-Xian Pan et al.
Nikolai Jaschke et al.
The steady rise in opioid users and abusers has uncovered multiple detrimental health consequences of perturbed opioid receptor signaling, thereby creating the need to better understand the biology of these systems. Among endogenous opioid ...
DAPA-CKD: Significant Victory for CKD with or without Diabetes [0.03%]
DAPA-NRD：无论是否有糖尿病对肾病患者而言达格列净都显著有效
Ankit B Patel,Kavita Mistry,Ashish Verma
Ankit B Patel
Sodium glucose cotransporter 2 inhibitors (SGLT2i) have revolutionized the treatment of heart failure and diabetic kidney disease. The DAPA-CKD trial by Heerspink et al. evaluated primary kidney outcomes with dapagliflozin in both diabetic ...
Sanjay Rajagopalan,Peter Pronovost,Ian J Neeland
Sanjay Rajagopalan
Deficiencies in the care of patients with diabetes are the norm rather than the exception. We propose a reframing of diabetes care quality, which encompasses four key principles ('the 4 BEs') that together can help address deficiencies in t...
Micol Falabella,Hilary J Vernon,Michael G Hanna et al.
Micol Falabella et al.
Over the past decade, it has become clear that lipid homeostasis is central to cellular metabolism. Lipids are particularly abundant in the central nervous system (CNS) where they modulate membrane fluidity, electric signal transduction, an...
Finerenone: A Non-steroidal Mineralocorticoid Receptor Blocker for Diabetic Kidney Disease [0.03%]
非那明：用于糖尿病肾病的非甾体盐皮质激素受体拮抗剂
Ashish Verma,Ankit B Patel
Ashish Verma
Hemodynamic alterations, metabolic dysfunction, inflammation, and fibrosis are the main drivers of diabetic kidney disease (DKD) progression. Targeting inflammation and fibrosis as a driver, the FIDELIO-DKD (Effect of Finerenone on Chronic ...
Endocrine Factors in Key Structural and Intracellular Changes in Depression [0.03%]
抑郁症发病关键结构和细胞内改变中的内分泌因素
Philip W Gold
Philip W Gold
Endocrine disturbances play predominant roles in recently discovered, clinically relevant abnormalities in depression. These affect multiple sites in the prefrontal cortex, amygdala, hippocampus, nucleus accumbens, and habenula. Deficits co...
Salim Khiati,Dominique Bonneau,Guy Lenaers
Salim Khiati
Anticipating very long space trips, da Silveira et al. performed pan-omic analyses on in-flight samples from astronauts, mice, and cells. Results revealed major mitochondrial dysfunctions responsible for alterations in metabolism, immunity,...
Sivaraj Mohana Sundaram,Markus Schwaninger
Sivaraj Mohana Sundaram
The underlying mechanism of oxytocin (OT) neurons in the development of social interaction remains unclear. In a recent study, Lewis et al. characterized OT neuronal subtypes and provided evidence that expression of the autism spectrum diso...